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securinine/securinega
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L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation.
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L-securinine is a natural product extracted and isolated from the leaf of dried Securinega suffruticosa. The aim of the present study was to explore the effects of L-securinine on proliferation, and the methylation profile of the dickkopf-related protein 1 (DKK1) gene in human lung cancer cells and
Securinine suppresses osteoclastogenesis and ameliorates inflammatory bone loss
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Securinine (Sec) is a naturally derived compound separated from the roots of Securinega suffruticosa, which has long been used as a herbal medicine. Sec is widely known as a GABA receptor antagonist, it is also known as an innate immune cell agonist and has been reported to increase macrophage
Development and validation of LC-MS/MS method for quantitative determination of (-)-securinine in mouse plasma.
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(-)-Securinine (SE) is a major alkaloid found in plant Securinega suffruticosa, which has a wide range of pharmacological activities including anticancer, anti-parasitic and central nervous system stimulating effects, etc. To aid the pharmacological study of SE, we developed an LC-MS/MS method for
Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells.
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Natural products have been discovered to be valuable sources of antitumor drugs. L-Securinine is a natural product extracted from the leaves or roots of Securinega suffruticosa Pall Rehd. The current study was done to investigate the molecular mechanisms of antitumor effects of L-securinine. The
Toxoplasma gondii: inhibitory activity and encystation effect of securinine and pyrrolidine derivatives on Toxoplasma growth.
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Securinine, an alkaloid originally isolated from Securinega suffruticosa, exhibits a wide range of biological activities, including anti-malarial activity. Along with securinine, 10 pyrrolidine derivatives, generated via the retrosynthesis of (-)-securinine, were selected and tested for their
Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase.
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Thioredoxin reductase (TrxR) and thioredoxin (Trx) are two major components of the thioredoxin system, which plays essential roles in regulating cellular redox signaling. Mammalian TrxRs are essential seleno-flavoenzymes with a conserved penultimate selenocysteine (Sec) residue at the C-terminus,
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.
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Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target
SmI2-mediated radical coupling strategy to Securinega alkaloids: total synthesis of (-)-14,15-dihydrosecurinine and formal total synthesis of (-)-securinine.
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The asymmetric total synthesis of (-)-14,15-dihydrosecurinine and the formal total synthesis of (-)-securinine were accomplished starting from an easily available malimide. A concise SmI2-mediated radical coupling strategy has been developed to construct the bridged α-hydroxy
An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.
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[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.
A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine.
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The syntheses of securinine and (-)-allonorsecurinine have been achieved starting from easily available alpha-amino acid derivatives and using as key steps a RCM and a Heck reaction for the formation of rings D and C, respectively. [reaction: see text]
Enantioselective approach to Securinega alkaloids. Total synthesis of securinine and (-)-norsecurinine.
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The most representative securinega alkaloids have been synthesized through a new strategy involving the palladium-catalyzed enantioselective allylation of a cyclic imide, a vinylogous Mannich reaction, and a ring-closing metathesis process, as the key steps. The diastereoselectivity of the
Viability of a [2 + 2 + 1] Hetero-Pauson-Khand Cycloaddition Strategy toward Securinega Alkaloids: Synthesis of the BCD-Ring Core of Securinine and Related Alkaloids.
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Preliminary results related to the development of [2 + 2 + 1]-oxa-hetero-Pauson-Khand cycloaddition strategy toward the Securinega alkaloids are reported. The critical tricyclic BCD-ring core was assembled in only nine linear steps from cheap 4-hydroxy-l-proline. The study provides valuable insight
[DETERMINATION OF SECURININE AND ITS STEREOISOMERS IN PLANTS OF THE SECURINEGA SPECIES, AND ISOLATION OF VIROALLOSECURININE AND VIROSINE].
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[Studies on securinine. I. Isolation and correlation of Securinega alkaloids].
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[Cultivation experiments of securinega suffruticosa Rehd. as securinine source. IV].
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