Effects of Dietary Supplements on Response to Air Pollution
Cuvinte cheie
Abstract
Descriere
The study will be conducted in Cache County, UT. Surrounded by tall mountains (2513-3042 m), and subject to frequent winter atmospheric inversions characterized by stagnant air that traps and concentrates pollutants, Cache Valley, home to 120,000 inhabitants, is particularly susceptible to high particulate air pollution during the winter months.
A total of 70 individuals (with the goal of completing 60) between the ages of 45-80 will be recruited from Cache County, UT. Eligible participants will be randomly assigned to one of two treatment arms (Placebo Dietary Supplements, Active Dietary Supplements) in a manner to provide balanced assignment between the two arms with respect to age, sex and baseline exhaled nitric oxide levels.
Participants assigned to the Placebo or Active arms will be provided with sealed envelopes or bottles containing dietary supplements (or matched placebos) along with instructions as to when to consume the supplements. Participants will be instructed to consume their supplements twice a day with meals containing a small amount of fat (at least 3 grams) in order to optimize the absorption of fat soluble nutrients. They will also be instructed to consume the supplements with liquids in order to enhance absorption and to minimize GI upset and choking potential. Participants will be asked to maintain their typical diet for the 18 weeks of the study.
Routine Clinic Visits are scheduled at two week intervals for the length of the study (with accommodations made for Holiday schedules). During these visits, participants will: 1) receive a sufficient supply of supplements to last until the next routine clinic visit; 2) return any unused supplements; 3) be provided an opportunity to describe any adverse events/reactions to the supplements; 4) describe any health issues experienced since the previous exam; and 5) have their weight and blood pressure assessed.
Endpoint Clinic Visits are scheduled to coincide with low and high PM2.5 exposure. Starting on Jan 2, participants will be notified of a potential endpoint assessment day when the PM2.5 levels are predicted by the Utah Department of Environmental Quality, Division of Air Quality, to rise above 30 µg/m3 (peak event) or fall below 8 µg/m3 (baseline event). Endpoint visits will take place 24 hrs following these peak and baseline events. Based on historical patterns, we anticipate at least three peak events, with corresponding baseline assessments, during the intervention time period. For purposes of analysis, each peak event will be paired with the nearest baseline event so that both events are captured at a similar time after initiation of the intervention.
At each endpoint clinic visit, participants will undergo assessments of lung function and systemic inflammation. Blood samples will be obtained for potential future analysis of additional markers of systemic inflammation and plasma antioxidant capacity.
Datele
| Ultima verificare: | 07/31/2012 |
| Primul depus: | 12/05/2011 |
| Inscriere estimată trimisă: | 12/06/2011 |
| Prima postare: | 12/07/2011 |
| Ultima actualizare trimisă: | 08/13/2012 |
| Ultima actualizare postată: | 08/14/2012 |
| Data actuală de începere a studiului: | 10/31/2011 |
| Data estimată de finalizare primară: | 02/29/2012 |
| Data estimată de finalizare a studiului: | 05/31/2012 |
Stare sau boală
Intervenție / tratament
Dietary Supplement: Placebo dietary supplements
Dietary Supplement: Active dietary supplements
Fază
Grupuri de brațe
| Braţ | Intervenție / tratament |
|---|---|
| Placebo Comparator: Placebo dietary supplements Visually identical inactive dietary supplement pack | Dietary Supplement: Placebo dietary supplements 7-pill placebo dietary packed visually identical to active dietary supplement |
| Experimental: Active dietary supplements Combination of antioxidants, minerals, fish oil, proflavanol and vitamin D | Dietary Supplement: Active dietary supplements A combination of dietary supplements including: β-carotene, vitamin C, vitamin D3, vitamin E, vitamin K, thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, biotin, pantothenic acid, calcium, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, boron, silicon, vanadium, eicosapentaenoic acid, docosahexaenoic acid, olive extract, mixed tocopherols, bioflavonoids, inositol, choline, N-acetyl L-cysteine, bromelain, coenzyme Q10, turmeric extract, lutein, lycopene, broccoli concentrate, grape seed extract |
Criterii de eligibilitate
| Vârste eligibile pentru studiu | 45 Years La 45 Years |
| Sexe eligibile pentru studiu | All |
| Acceptă voluntari sănătoși | da |
| Criterii | Inclusion Criteria: - Male or female of any race or ethnicity - Body Mass Index (BMI) between 19 - 34 kg/m2 - Non-smoking status - Willing to consume assigned dietary supplements for 18 weeks. Exclusion Criteria: - BMI <19 or >34 kg/m2 - Uncontrolled hypertension defined as diastolic blood pressure >=95 mm Hg or systolic blood pressure >=160 mm Hg - Documented presence of atherosclerotic disease and/or cardiopulmonary disease - History of frequent falls - History of drug or alcohol abuse - History of unstable depression or mental illness within the last 6 months for which the PI believes could impact the participant's ability to comply with study requirements - Unwilling to discontinue use of conventional multivitamin/mineral or other supplements at least two weeks prior to the study start - Participating in or planning to begin a weight loss diet during the study period - Chronic use of over-the-counter medication which would interfere with study endpoints including NSAIDS, laxatives and antacids - Difficulty in swallowing pills - Lifestyle or schedule incompatible with the study protocol |
Rezultat
Măsuri de rezultate primare
1. Forced vital lung capacity (FVC) [Six times over 3 months to coincide with high and low PM2.5 exposure]
Măsuri de rezultate secundare
1. Forced expiratory volume in first second (FEV1) [Six times over 3 months to coincide with high and low PM2.5 exposure]
2. Fractional exhaled nitric oxide (FeNO) [Six times over 3 months to coincide with high and low PM2.5 exposure]
3. C-reactive protein [Six times over 3 months to coincide with high and low PM2.5 exposure]
