Hereditary fructose intolerance and celiac disease: a novel genetic association.
Cuvinte cheie
Abstract
OBJECTIVE
Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI).
METHODS
We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients.
RESULTS
Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P<.02).
CONCLUSIONS
The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.
