Molecular Mechanisms of Action of Myricetin in Cancer.

Natural compounds such as paclitaxel and camptothecin have great effects on tumor treating. Such natural chemicals often achieve anti-tumor effects through a variety of mechanisms. Therefore, it is of great significance to push forward the studies on the anticancer mechanism of natural anticancer to lay a solid foundation for the development of new drugs. Myricetin, originally isolated from Myrica nagi, is a natural pigment of flavonoids which can inhibit the growth of cancer cells (such as liver cancer, rectal cancer, skin cancer and lung cancer, etc.). It can regulate many intracellular activities (such as anti-inflammatory and blood lipids regulation) and can be even bacteriostatic. The purpose of this paper is to outline the molecular pathways of Myricetin's anticancer effects, including the effect on cancer cell death, proliferation, angiogenesis and metastasis and cell signaling pathway.