Anti-obesity effect of plant diterpenes and their derivatives: A review.

Obesity is a medical condition in which excess body fat is accumulated by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. Obesity increases the risk of various diseases and conditions, including cardiovascular diseases, diabetes, cancer, and depression. This review focuses on most recent reports pertaining to the antiobesity activity of plant-derived diterpenes in different databases. For this, a search (until August 2019) was conducted in the PubMed and Science Direct databases with the following keywords: "plant diterpenes" or "plant diterpenoids" paired with "obesity" or "antiobesity effects." Overall, 729 references that used the aforementioned keywords were selected, among which 34 articles have been included in this review. Results from this search suggest that a number of diterpenes and their derivatives have been found to exert antiobesity effects through various mechanisms, such as overweight reduction or modification of body mass index, protein-tyrosine phosphatase 1B inhibition, lipase activity inhibition, antiadipogenesis effect, among others. Carnosic acid, carnosol and the derivatives of abietic acid, steviol, and andrographolide are examples of important antiobesity diterpenes and their derivatives. Of note, plant-derived diterpenes may be potential candidates for managing obesity and obesity-related diseases and disorders in human and other animals.