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Teratogenicity of cytochalasin D in chick embryos.

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The effects of cytochalasin D on chick embryos were analyzed in the present study. Cytochalasin D was dissolved in DMSO and injected into embryonating chicken eggs at dosages ranging from 0.001 to 0.014 mg per egg. The injections were made into the air sacs of eggs at days 0, 1, 2 and 3 of

Evaluation of teratogenic potential of cyfluthrin, a synthetic pyrethroid in Swiss albino mice.

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A toxicity study was planned to assess the teratogenic potential of cyfluthrin that is widely used as a household insecticide to control mosquitoes, flies and cockroaches. Pregnant Swiss albino mice of one group were orally administered two doses of the pesticide (16 mg/kg and 32 mg/kg body weight)

[Cardiac and great vessel abnormalities in rat fetuses with external malformations induced by hyperthermia].

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Pregnant rats at day 9 were bathed in 43 degrees C water for 15 min. Maternal rats at day 15 of gestation were found pregnant with fetuses variously malformed externally, such as exencephaly, spina bifida, microphthalmia, anophthalmia, facial cleft, cleft lip and generalized edema. Fetal death

Conduction system abnormalities in rat embryos induced by maternal hyperthermia.

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Maternal hyperthermia induces severe malformations in the central nervous system (CNS) in both humans and laboratory animals. These phenomena are accompanied by apoptotic cell death, especially in the developing CNS. Cardiovascular malformations in conjunction with skeletal and CNS abnormalities

Comparative effects of prenatal cocaine, alcohol, and undernutrition on maternal/fetal toxicity and fetal body composition in the Sprague-Dawley rat with observations on strain-dependent differences.

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Pregnant rats received either 20, 30, 40, or 50 mg/kg cocaine HCl (SC) twice daily from gestation days 7 through 19. Pair-fed and untreated control groups and a group receiving 3.0 g/kg alcohol (PO) twice daily served as comparison groups. Females were sacrificed on gestation day 20 and the fetuses

Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis.

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The present investigation was conducted to evaluate the teratogenic and developmental toxicity of fluoride and endosulfan alone and in combination in pregnant Swiss albino mice exposed during the organogenetic period (5-14 days) of gestation. Fluoride (25.1 mg/kg body weight in water) and endosulfan

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