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Plasma tumour necrosis factor alpha in cystic fibrosis.

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Plasma tumour necrosis factor alpha (alpha) concentration is increased in acute Gram negative sepsis, but the effect of chronic infection on plasma concentrations is unknown. A study was carried out in patients with cystic fibrosis to determine the effect of chronic lung infection with Pseudomonas

In vitro tumor necrosis factor-alpha secretion by monocytes from patients with cystic fibrosis.

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Immunoreactive tumor necrosis factor-alpha (TNF-alpha) concentration is increased in plasma from patients with cystic fibrosis and chronic Pseudomonas aeruginosa pulmonary infection. To determine if circulating monocytes could be the source of plasma TNF-alpha, we determined in vitro basal and

The clinical features of severe community-acquired pneumonia presenting as septic shock. Norasept II Study Investigators.

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OBJECTIVE The purpose of this article was to determine the outcome, clinical and prognostic features, and microbiology of a large group of patients with community-acquired pneumonia (CAP) presenting in septic shock. METHODS The placebo limb of the Norasept II database was examined. Data were

Experimental sepsis using Pseudomonas aeruginosa: the significance of multi-drug resistance.

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In order to clarify whether susceptible and multidrug-resistant Pseudomonas aeruginosa differ in the mechanism of induction of sepsis, three different isolates were used; one susceptible (isolate A) and two (isolates B and C) multidrug-resistant. Isolate B had moderately elevated MICs of

Bacteremia caused by non-sporulating anaerobes in cancer patients. A 12-year experience.

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The clinical, epidemiological and laboratory characteristics of bacteremia caused by anaerobic organisms other than Clostridium spp. in cancer patients are described and compared to other previously reported series. Of the 315 episodes, 246 (78%) were caused by a single organism and 69 (22%) were

Malignant external otitis: a case report and review.

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Malignant external otitis is an unusual but serious and potentially fatal condition that has only recently been described. It is an invasive pseudomonal infection of the external auditory canal and deep periauricular tissues that characteristically involves the bone and adjacent cartilaginous

Malignant otitis externa: a review.

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Malignant otitis externa is a rare but potentially fatal disease of the external auditory canal seen mostly among elderly, diabetic or immunocompramised patients. The causative organism is mainly Pseudomonas aeruginosa. The disease spreads rapidly, invading surrounding soft tissues, cartilage and

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