aristolochic acid a/aristolochia

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[The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats].

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OBJECTIVE To study and approach the processing methods and mechanism which can markedly reduce the content of aristolochic acid in Aristolochia manshuriensis and lighten the nephrotoxicity of aristolochic acid. METHODS A traditional "attenuation" processing method was used and 30 types of samples

[Determination of aristolochic acid A in Radix Aristolociae and Herba Asari by RP-HPLC].

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OBJECTIVE To develop a HPLC method to determine the contents of aristolochic A in aristolochia debilis and Asarun spp.. METHODS Methanol-water-formic acid extracts were separated on an Alltech C18 column with methanol-water-acetic acid (68:32:1) as mobile phase. The flow rate was 1.0 mL x min(-1).

[The pregnancy terminating effect and toxicity of an active constituent of Aristolochia mollissima Hance, aristolochic acid A].

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Endemic nephropathy: the case for chronic poisoning by aristolochia.

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OBJECTIVE To explore the hypothesis that chronic dietary poisoning by aristolochic acid could account for the unique geographical distribution, specific pattern of tubulointerstitial fibrosis, occurrence of chronic renal insufficiency, and an increased risk of developing upper urothelial cancer, all

[Nephrotoxicity of Aristolochia manshuriensis and aristolochic acids in mice].

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OBJECTIVE The acute toxic effects of Aristolochia manshuriensis (GMT) and the total aristolochic acids (TA) were compared in mice with aristolochic acid A (AA) as the dose standard. The dose relationship of the renal toxicity induced by Aristolochia manshuriensis was determined. METHODS A single

Induction of structural chromosome aberrations and sister chromatid exchanges in human lymphocytes in vitro by aristolochic acid.

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The medicinal use of Aristolochia clematitis has been known for some time. The main active agent of this medicinal plant is aristolochic acid, a nitrophenanthrenecarbonic acid. Very recently, however, the Federal Health Office withdrew the licence for all drugs containing aristolochic acid, because

Analysis of products suspected of containing Aristolochia or Asarum species.

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Aristolochia species have been administered by those trained in traditional Chinese medicine (TCM) for centuries. After determining Aristolochia fangchi was an adulterant that caused death due to renal failure in a number of patients at a Belgian weight loss clinic, many countries took steps to

Differentiation between two "fang ji" herbal medicines, Stephania tetrandra and the nephrotoxic Aristolochia fangchi, using hyperspectral imaging.

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Stephania tetrandra ("hang fang ji") and Aristolochia fangchi ("guang fang ji") are two different plant species used in Traditional Chinese Medicine (TCM). Both are commonly referred to as "fang ji" and S. tetrandra is mistakenly substituted and adulterated with the nephrotoxic A. fangchi as they

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