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The Gaboon viper, Bitis gabonica: hemorrhagic, metabolic, cardiovascular and clinical effects of the venom.
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The effects of Bitis gabonica venom have been studied in several animal species, including the monkey, dog, rabbit, rat and guinea pig. Further information has been provided by observations on the effects of snake bite in man. Bitis gabonica venom exerts a number of cytotoxic and cardiovascular
Isolation and characterisation of two haemorrhagic proteins (HTa and HTb) from the venom of Bitis gabonica (Gaboon viper).
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Two distinct haemorrhagic proteinases, HTa and HTb, were isolated from the venom of Bitis gabonica by gel filtration and ion-exchange chromatography with native mol. wts of 180,000 and 111,000, respectively. After reduction with dithiothreitol, smaller mol. wts of 77,600 and 69,200 were recorded for
Gaboon viper (Bitis gabonica) envenomation resulting from captive specimens--a review of five cases.
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BACKGROUND
Five cases of illegitimate bite by captive specimens of the Gaboon viper (Bitis gabonica) snake have demonstrated the dangers of keeping exotic African snakes in captivity.
METHODS
Four cases necessitated hospitalization for the bite and were characterized by progressive swelling of the
The effect of Gaboon viper venom on iron exchange in the rat.
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Plasma iron turnover (PIT) has been measured by means of 59Fe in rats treated with the haemorrhagic venom of the Gaboon viper (Bitis gabonica). Venom was administered on 3 occasions over a period of 9 days and after this time PIT had fallen from 1045 micrograms/kg/day in normal animals to 449
Comparison of the physiological effects in rabbits of gaboon viper (Bitis gabonica) venoms from different sources.
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The cardiovascular, respiratory and metabolic effects of B. gabonica venoms obtained from specimens originating from Ghana, Togo, Nigeria, Uganda and Tanzania were examined in anaesthetized rabbits. Intravenous injection of all venoms (0.125-2.0 mg/kg) induced hypotension. Nigeria venom was the
The effect of Bitis gabonica (Gaboon viper) snake venom on external iliac and mesenteric arterial circulation in the dog.
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The effects of Gaboon viper (Bitis gabonica) venom on external iliac and mesenteric arterial blood flow and resistance were investigated in eight anaesthetized, close-chest dogs. Venom doses in the range 0.125-0.5 mg/kg produced a profound fall in external iliac and mesenteric arterial resistance,
Adenosine in the venoms from viperinae snakes of the genus Bitis: identification and quantitation using LC/MS and CE/MS.
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Snake venoms are rich sources of toxic proteins and small molecules. This study was directed at molecules of molecular mass below 1 kDa. Thirty different venoms, of either neurotoxic or haemorrhagic type, were fractionated using size-exclusion chromatography. Only venoms of the Puff adder (Bitis
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