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choledocholithiasis/glutation
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Severe INR elevation in a patient with choledocholithiasis receiving cefoperazone.
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Cefoperazone is a third-generation cefalosporin that contains the N-methyl- thio-tetrazole (NMTT) side chain, which inhibits vitamin K-dependent carboxylation. Administration of NMTT-containing cefalosporins can cause alterations in the hepatic glutathione redox state, resulting in a dose-related
Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS.
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Previous work from this laboratory has reported the biotransformation of bile acids (BA) into the thioester-linked glutathione (GSH) conjugates via the intermediary metabolites formed by BA:CoA ligase and shown that such GSH conjugates are excreted into the bile in healthy rats as well as rats dosed
Inflammatory mediators and surgical trauma regarding laparoscopic access: free radical mediated reactions.
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In this prospective study the free radical mediated reactions, the changes of endogenous antioxidant defense mechanism and activation of leukocytes were measured from the blood of patients undergoing elective cholecystectomy because of symptomatic cholecystolithiasis. The patients were randomised
Maximal biliary transport of sulfobromophthalein in patients with a T-tube placed in the common bile duct.
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In 19 adult patients with choledocholithiasis who were operated on, excretion of free and conjugated sulfobromophthalein (BSP) in the bile collected through a T-tube inserted in the common bile duct was determined. The transport maximum (Tm) for BSP was calculated by the constant-infusion technique
Effects of obstructive jaundice on the antioxidative capacity of human red blood cells.
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Transient haemolysis and shortened erythrocyte lifespan are reported in association with extrahepatic biliary tract obstruction. An increase in lipid peroxidation has been noted as evidence of oxidative damage in red cells due to cholestasis. The influence of surgical relief on the antioxidative
Usefulness of bile as a biomarker via ferroptosis and cysteine prenylation in cholangiocarcinoma; role of diagnosis and differentiation from benign biliary disease
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Background: Cholangiocarcinoma (CCA) is a malignant cancer of the biliary tract with a poor prognosis. Herein, we investigated possible mechanism of extrahepatic CCA (eCCA) by dysregulated iron metabolism and post-translational
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