cicutoxin/cicuta

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Effects of cicutoxin and related polyacetylenes from Cicuta virosa on neuronal action potentials: a comparative study on the mechanism of the convulsive action.

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Cicutoxin, the convulsant principle of water hemlock, Cicuta virosa L., and the related polyacetylenes isocicutoxin, cicudiol, cicutol, falcarindiol, and falcarinol (20-100 micromol/l) were investigated concerning their influence on electrophysiological parameters using the giant cell RPD1 of the

Cicutoxin from Cicuta virosa--a new and potent potassium channel blocker in T lymphocytes.

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The effect of cicutoxin, the poisonous principle of the genus Cicuta, on K+ currents of activated T lymphocytes was investigated using the patch clamp technique. Cicutoxin produced a dose-dependent [5 x 10(-6) to 7 x 10(-5) mol/l] and completely reversible block of K+ currents with an EC50 of 1.8 x

Antitumor agents, 85. Cicutoxin, an antileukemic principle from Cicuta maculata, and the cytotoxicity of the related derivatives.

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The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers.

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Water hemlocks (Cicuta spp.) are acutely toxic members of the Umbellierae family; the toxicity is due to the presence of C17-polyacetylenes such as cicutoxin. There is only limited evidence of noncompetitive antagonism by C17-polyacetylenes at GABAA receptors. In this work with WSS-1 cells, we

Polyacetylenes from water hemlock, Cicuta virosa.

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Isolation of polyacetylenes from aerial and subterranean parts of water hemlock, Cicuta virosa L. (Apiaceae. Apioideae), yielded eleven C (17)-polyacetylenes: cicutoxin, cicutol, (8 E,10 E)-heptadecadiene-4,6-diyne-1,12-diol (cicudiol, 7), 2,3-dihydrooenanthetol and (8

Water hemlock poisoning in cattle: Ingestion of immature Cicuta maculata seed as the probable cause.

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It is well understood that water hemlock tubers are highly toxic to animals and to humans. However, this is the first time that immature seed from (Cicuta maculata) has been implicated in livestock poisoning. Nine mature Hereford cows from a herd of 81 died in northwestern Utah after ingesting

Exploring the structural basis of neurotoxicity in C(17)-polyacetylenes isolated from water hemlock.

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Water hemlock, Cicuta virosa, belonging to the Umbelliferae, is well-known as a toxic plant responsible for lethal poisonings in humans as well as animals, causing tonic and clonic convulsions and respiratory paralysis. Cicutoxin (1), being a major violent toxin of the plant, is a chemical in the

Cicuta toxicosis in cattle: case history and simplified analytical method.

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Poisoning of cattle by water hemlock roots is a common occurrence. The experience of our Pathology Branch has been that the roots will be found in the esophageal groove with no obvious signs of root in the rumen. Confirmation of the presence of cicuta poisoning is done by analysis for cicutoxin in

Toxicoses in livestock from the hemlocks (Conium and Cicuta spp.).

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The hemlocks, Conium maculatum (poison-hemlock) and Cicuta spp. (waterhemlock), are poisonous plants that cause sizeable losss to the livestock industry. Clinical signs of poisonhemlock toxicosis are similar in all species of livestock and include muscular weakness, incordination, trembling, initial

A fatal case of apparent water hemlock poisoning.

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A 14-y-o North American native boy died 20 h after ingesting "wild carrot". He was gathering edible plants with his family on Canadian Thanksgiving. A sample of the plant he ingested couldn't be positively identified but it contained cicutoxin on chromatography. Bioassay caused death in mice which

New aspects in the treatment of water hemlock poisoning.

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A man inadvertently ate a whole root of the highly poisonous water hemlock (Cicuta virosa L.) plant. The chief symptoms were convulsions, unconsciousness, reddish tinted cyanosis, dilated pupils and marked metabolic acidosis. The patient survived due to treatment with haemodialysis, haemoperfusion,

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