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Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils.

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Saffron, the stigma of Crocus sativus Linné (Iridaceae family), has been known to inhibit aggregation of β-amyloid, a nerve tissue protein. α-Synuclein (αS) is a 140-amino acid protein found abundantly in various regions of the brain. Its abnormal aggregation and accumulation in nerve tissue are

Regulated preparation of crocin-1 or crocin-2' triggered by the co-solvent DMSO using Bs-GT/At-SuSy one-pot reaction.

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Crocins are the primary coloring ingredients of saffron. The low-glycosylated members of this compound family, such as crocin-1(crocetin mono-glucosyl ester) and crocin-2' (crocetin di-glucosyl ester), are rarely distributed in nature and attracting interest in their therapeutic uses. In our

The effects of crocin on the symptoms of depression in subjects with metabolic syndrome.

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BACKGROUND Studies have suggested that metabolic syndrome (MetS) is associated with increased depressive symptoms, and reducing depression in subjects with MetS is important. Crocin, an active component of saffron, has useful properties for subjects with MetS, including antidepressant

Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography.

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A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed for the first time to simultaneously quantify the five major biologically active ingredients of saffron, namely crocin 1, crocin 2, crocin 3, crocin 4 and crocetin. Calibration curves were

[In vitro evaluation of the chemopreventive potential of saffron].

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Cancer is a very important national health problem in Mexico, while a significant increase in the total and childhood cancer mortality has been recorded during the last decades. Chemoprevention, defined as the use of natural or synthetic agents to prevent or to block the development of cancer in

Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells.

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In this study, we investigated the role of mitogen-activated protein kinase (MAPK) signaling pathways in mediation of the protective effects of saffron extract, saffron essential oil, safranal and crocin on bovine aortic endothelial cells against oxidative injury. The viability of cells in response

Structural characterization of highly glucosylated crocins and regulation of their biosynthesis during flower development in Crocus.

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Crocin biosynthesis in Crocus has been proposed to proceed through a zeaxanthin cleavage pathway catalyzed by carotenoid cleavage dioxygenase 2 (CCD2), and followed by glucosylation reactions catalyzed by CsGT2 (UGT74AD1). In Crocus ancyrensis flowers, crocins with eight (crocin-1), seven

Discrimination of Different Parts of Saffron by Metabolomic-Based Ultra-Performance Liquid Chromatography Coupled with High-Definition Mass Spectrometry.

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In this study, the metabolite profiling of three different parts of Crocus sativus L. was measured by using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTof-MS/MS). Multivariate statistical analysis was used to distinguish among the samples from

Antidepressant properties of bioactive fractions from the extract of Crocus sativus L.

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The aim of this study was to investigate the antidepressant properties of stigmas and corms of Crocus sativus L. The aqueous ethanol extract of C. sativus corms was fractionated on the basis of polarity. Among the different fractions, the petroleum ether fraction and dichloromethane fraction at

Effects of crocin analogs on ocular blood flow and retinal function.

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Ischemic retinopathy and age-related macular degeneration are the leading ocular diseases that cause blindness. The etiology of these diseases is due in part to the reduction of blood flow in the retina and/or choroid. Crocin analogs isolated from Crocus sativus L. were found to significantly

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