This arm will receive a supplementation with Zinc and Myo-inositol once a day.

This arm will receive a supplementation with a same product equal to the active product but without Zinc and Myo-inositol inside.

Obesity, Childhood

Insulin Resistance

Zinc Deficiency

Inositol

In this active Group there will be a supplementation with Zinc (5 mg), Myo-inositol (2000 mg) and GOS (Galacto-oligosaccharides) of Pisum sativum (1000 mg)

Zinc

In this placebo Group there will be a supplementation with a product placebo equal to the active product with GOS (Galacto-oligosaccharides) of Pisum sativum(1000 mg) but without Zinc and Myo-inositol.

Placebos

Myoinositol

AOU Maggiore della Carità - Clinica Pediatrica - Ambulatorio di Auxologia ed Endocrinologia Pediatrica

ZIMBA: Clinical Trial in Paediatric Obesity

Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity

Evaluate if after the treatment with Myoinositol and Zinc supplementation there is a variation of HOMA-IR index.
Evaluate if after the treatment with probiotic there is a variation of HOMA-IR index.

Evaluate if after the treatment with Myoinositol and Zinc supplementation there is a reduction of glucose values during the OGTT at time 0' e 120' after oral glucose tolerance test.

Evaluate any variation of serum lipids, leptin, adiponectin, GLP1 and insulin during OGTT.

Evaluate new cytokines and metabolites that regulates hormone metabolism.

Simonetta Bellone

Assoc. Professor

Azienda Ospedaliero Universitaria Maggiore della Carita

The study is a triple blind study in which the treatment or intervention is unknown to the research participant, the individuals who administer the treatment or intervention, and the researchers who assess the outcomes.

Myo-inositol plus D-chiro inositol 550mg/13,8 mg twice a day

Gestational Diabetes Mellitus

Folic acid

Myo-inositol

D-Chiro-inositol

Myo-inositol plus D-chiro inositol

Hospital "SS Annunziata"

Inositol Stereoisomers to Treat Gestational Diabetes

Different Effects of Inositol Stereoisomers on Insulin Sensitivity in Women With Gestational Diabetes

Ester Vitacolonna

Professor Ester Vitacolonna

Università degli Studi 'G. d'Annunzio' Chieti e Pescara

Diet pills of 400 mcg of acid folic daily

Diet sachets 2000 mg myo-inositol and 250 mg d-chiro-inositol and 400 mcg folic acid daily

Diet pills with 500 mg d-chiro-inositol and 400 mcg folic acid daily

Diet sachets with 2000 mg myo-inositol and 200 mcg folic acid twice daily

Dietary control plus D-Chiro-Inositol supplementation

D-chiro-inositol

Dietary control Supplementation with myo and d-chiro inositol

D-Chiro / Myo-inositol

Dietary control plus folic acid 400 mcg daily

Placebo

Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes

Adverse Obstetric Outcomes in Gestational Diabetes Mellitus and Inositol Stereoisomears

OGTT is the mainstay of obstetric outcomes in GDM

Centiles of fetal measurements and amniotic fluid volume

Gestational age at delivery Route of delivery Fetal gender Fetal weight (grams and centiles) Neonatal hypoglycemia

Abortion Preterm delivery Polyhydramnios IUGR Macrosomia Fetal distress Preterm delivery pPROM Neonatal morbility (NICU stay, low glucose levels, etc.) Neonatal mortality Cerebral palsy Route of delivery Dystocia Etc.

Claudio Celentano

G. d'Annunzio University

University of Chieti

PCOS women receiving weight loss intervention

Non-PCOS women receiving weight loss intervention

d chiro inositol/diabet zaharat

ZIMBA: Clinical Trial in Paediatric Obesity

Inositol Stereoisomers to Treat Gestational Diabetes

Myo-inositol, D-chiro-inositol, and D-chiro/Myo-inositol in Gestational Diabetes

Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study

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