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Comparative oral and topical decongestant effects of phenylpropanolamine and d-pseudoephedrine.

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Nonselective adrenergic alpha-agonists such as phenylpropanolamine and d-pseudoephedrine are widely used as decongestants to treat nasal congestion associated with a variety of nasal diseases. Although the activity of these drugs is well established in clinical studies, a direct comparison of their

Pharmacological characterization of a noninvasive, chronic, experimental dog model of nasal congestion.

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BACKGROUND The present experiments were undertaken to pharmacologically characterize a noninvasive, chronic, experimental dog model of nasal congestion with the overall goal of developing an effective tool for studying the mechanism of action of nasal decongestant drugs. METHODS Nasal patency was

Loratadine and montelukast administered in combination produce decongestion in an experimental feline model of nasal congestion.

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BACKGROUND Histamine and leukotrienes act to exert numerous local and systemic effects that contribute to the pathophysiology of allergic rhinitis. The aim of these experiments was to evaluate the nasal decongestant effects of loratadine and montelukast alone and in combination in a feline model of

Acoustic rhinometry in the dog: a novel large animal model for studies of nasal congestion.

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The aim of this project was to develop and pharmacologically characterize an experimental dog model of nasal congestion in which nasal patency is measured using acoustic rhinometry. Solubilized compound 48/80 (0.3-3.0%) was administered intranasally to thiopental anesthetized beagle dogs to elicit

Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion.

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Nasal congestion is one of the most troublesome symptoms of many upper airways diseases. We characterized the effect of selective α2c-adrenergic agonists in animal models of nasal congestion. In porcine mucosa tissue, compound A and compound B contracted nasal veins with only modest effects on

A model of allergic nasal congestion in dogs sensitized to ragweed.

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BACKGROUND Acoustic rhinometry is a noninvasive method that uses sound waves to measure dimensions of the nasal cavity. METHODS In this study, nasal patency was measured by acoustic rhinometry in allergic Beagle dogs sensitized to ragweed allergen. Ragweed (0.03-0.3%) or vehicle were administered

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