deoxyandrographolide/andrographis paniculata

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Deoxyandrographolide-19beta-D-glucoside from the leaves of Andrographis paniculata.

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A new diterpene glucoside has been isolated from the leaves of Andrographis paniculata and its structure elucidated as deoxyandrographolide-19beta-D-glucoside on the basis of chemical and spectral evidence. A detailed proton magnetic resonance study of the diterpene was crucial in the structure

Determination of andrographolide, deoxyandrographolide and neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography.

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In this paper a micellar electrokinetic capillary chromatographic (MEKC) method has been developed for determining the active components (andrographolide, deoxyandrographolide and neoandrographolide) in water:ethanol extracts of the Chinese crude herb Andrographis paniculata and its preparations

Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings.

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BACKGROUND The aim of the present study is to evaluate the possible mechanism of the vasorelaxant effect of the Andrographis paniculata chloroform extract (APCE) and diterpenoids, such as, 14-deoxyandrographolide (DA) and 14-deoxy-11, 12-didehydroandrographolide (DDA), on rat aortic

Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.

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A quantitative proton nuclear magnetic resonance technique (qHNMR) has been successfully introduced to quantify andrographolide, dehydroandrographolide, deoxyandrographolide and neoandrographolide in Andrographis paniculata, a commonly used important traditional Chinese medicine. Creative use of

Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells.

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The in vitro cytotoxicities of the ethanol extract of Andrographis paniculata (APE) and its main diterpenoid components were evaluated in various cancer cells. APE was found to be significantly growth inhibitory to human acute myeloid leukemic HL-60 cells with an IC (50) value of 14.01 microg/mL

[Research on UPLC-PDA fingerprint of andrographis paniculata and quantitative determination of 4 major constituents].

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Andrographis paniculata from different parts and origins were analyzed by UPLC-PDA fingerprint to provide refererice for related preparation technology. Using the peak of andrographolide as reference, 27 common peaks were identified, and digitized UPLC-PDA fingerprints for 23 batches of andrographis

[HPLC Specific Fingerprint of Alcohol Extract of Andrographis paniculata].

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OBJECTIVE To establish the specific fingerprint of alcohol extract of Andrographis paniculata by HPLC. METHODS The analysis was performed on Cosmosil 5C18 -MS-II (250 mm x 4. 6 mm, 5 µm) column, with gradient phase consisting of acetonitrile and water at the flow rate of 1. 0 mL/min. The UV

[Characteristic fingerprint analysis and determination of main components on Andrographis paniculata extract by UPLC].

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OBJECTIVE To establish an analytical method for characteristic fingerprint and determination of main components of Andrographis paniculata Extract by UPLC. METHODS The chromatographic conditions were Waters ACQUITY UPLC BEH-C18 (2. 1 mm x 0 mm,1.7 μm)by gradient elute using acetonitrile-water as

[Studies on diterpenoids from Andrographis paniculata].

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OBJECTIVE To study the diterpenoids in the 85% ethanol extract of the aerial parts of Andrographis paniculata. METHODS Fourteen diterpenoids from the 85% EtOH extract were isolated by the silica gel, Sephadex LH-20, ODS column chromatography and HPLC, and their structures were identified by the

Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval.

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To discover new natural-product-based pesticides, we structurally modified andrographolide, a labdane diterpenoid isolated from Andrographis paniculata, and stereoselectively prepared a series of 12α-(substituted)benzylamino-14-deoxyandrographolide derivatives (I-V). Three-dimensional structures of

Simultaneous determination of four andrographolides in Andrographis paniculata Nees by silver ion reversed-phase high-performance liquid chromatography.

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A rapid and sensitive silver ion high-performance liquid chromatographic (Ag[I]-HPLC) method is developed for the simultaneous determination of the biologically active diterpenoids andrographolide, 14-deoxy-11,12-didehydroandrographolide, 14-deoxyandrographolide, and neoandrographolide in

A Simple and Sensitive LC-MS/MS Method for Determination of Four Major Active Diterpenoids from Andrographis paniculata in Human Plasma and Its Application to a Pilot Study.

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Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous

Antifungal activity of Andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro.

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BACKGROUND Andrographis paniculata Nees. (Acanthaceae) is an annual herbaceous plant widely cultivated in southern Asia, China, and Europe. It is used in the treatment of skin infections in India, China, and Malaysia by folk medicine practitioners. OBJECTIVE Antifungal activity of the whole plant

A new diterpene from the leaves of Andrographis paniculata Nees.

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Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3,

ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.

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Two pairs of ent-labdane diterpenoid lactone stereoisomers (1- 4) including three new compounds (1- 3) were isolated from the 85% EtOH extract of the aerial parts of Andrographis paniculata. The structures of these compounds were identified as 7 R-hydroxy-14-deoxyandrographolide (1), 7

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