escin/hypoxia

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β-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1α/TGF-β/MMPs in A549 cells

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Hypoxia is contributed in various pathophysiological conditions including obesity, cardiovascular diseases, and cancer. In cancer, hypoxia is a salient phenomenon and has been correlated with tumor progression, metastasis, and provoke resistance to therapies in cancer patients, which exert with

Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.

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The effect of hypoxia was investigated in human (HPA) and rat (RPA) pulmonary arteries. Hypoxia-induced contraction was 95 +/- 8.7% and 9.3 +/- 4.8% of the control response to K(+)-rich (80 mM) solution in HPA and RPA, respectively (n = 10). When RPA strips were precontracted with phorbol 12,13

Ca(2+) sensitivity of fetal coronary arteries exposed to long-term, high-altitude hypoxia.

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OBJECTIVE To determine the contribution of decreased calcium responsiveness of fetal coronary arteries to decreased contractile responses to potassium and the thromboxane A(2) analogue U46619 in these arteries after exposure to chronic hypoxemia. METHODS Concentration-response curves to Ca(2+) in

PKC regulates alpha(1)-adrenoceptor-mediated contractions and baseline Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia.

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Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant

Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and Daflon.

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Escin, hydroxyethylrutoside (HR), and Daflon have been shown to be safe and effective for the treatment of chronic venous insufficiency (CVI). They seem to work differently than compression therapy, suggesting that they would usefully augment this therapy. All three phlebotonics attenuate the drop

Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression.

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The saponin fraction of Aesculus chinensis Bunge fruits (SFAC) could inhibit the invasion and migration of MDA-MB-231 cells. Among which, escin Ia showed more potent inhibition of the invasion than other five main saponin constituents. It selectively reduced the expression of LOXL2 mRNA and promoted

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties.

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This review discusses historical and recent pharmacological and clinical data on the anti-edematous, anti-inflammatory, and venotonic properties of escin (Reparil^®). Escin, the active component of Aesculus hippocastanum, or horse chestnut, is available as orally absorbable dragées

Ca2+-independent hypoxic vasorelaxation in porcine coronary artery.

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To demonstrate a Ca(2+)-independent component of hypoxic vasorelaxation and to investigate its mechanism, we utilized permeabilized porcine coronary arteries, in which [Ca(2+)] could be clamped. Arteries permeabilized with beta-escin developed maximum force in response to free Ca(2+) (6.6 microm),

[Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins].

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The aim of the study was to investigate the role of protein kinase C (PKC) in changes in myofilament Ca(2+)-sensitivity of vascular smooth muscle cells (SMC) in rats at different vasospastic states: hypoxic pulmonary vasoconstriction, genetically determined hypertension, and hypertension resulted

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