glaucine/tuse

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Double-blind study of glaucine in chronic cough.

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Thirty-eight patients, affected by chronic cough and hospitalized in 14 different rooms, entered a double-blind cross-over trial aimed at evaluating efficacy and tolerance of single oral doses of glaucine (eo mg) versus single oral doses of codeine (30 mg) and placebo. Patients occupying the same

The effects of drugs on cough.

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The pharmacologic treatment of cough can be divided into two main categories: therapy with controls, prevents or eliminates cough (i.e., antitussive) and therapy that makes cough more effective (i.e., pro-tussive). Definitive antitussive therapy depends on determining the aetiology or operant

Studies on the metabolism and toxicological detection of glaucine, an isoquinoline alkaloid from Glaucium flavum (Papaveraceae), in rat urine using GC-MS, LC-MS(n) and LC-high-resolution MS(n).

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Glaucine ((S)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo [de,g]quinoline) is an isoquinoline alkaloid and main component of Glaucium flavum (Papaveraceae). It was described to be consumed as recreational drug alone or in combination with other drugs. Besides this, glaucine is used

Objective evaluation of dextromethorphan and glaucine as antitussive agents.

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Twenty-four inpatients affected by chronic cough completed a single-dose double-blind cross-over study of placebo, glaucine 30 mg and dextromethorphan 30 mg. The study was carried out using a balanced incomplete block design, each patient receiving two of the three experimental treatments. Objective

Efficacy and tolerability of glaucine as an antitussive agent.

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One hundred and thirty out-patients, affected by acute and chronic cough caused by upper respiratory tract inflammation, took part in two clinical studies aimed at evaluating the efficacy and tolerability of glaucine , a new antitussive agent. The first study involved 90 patients in a double-blind

Objective assessment of cough suppressants under normal and pathological experimental conditions.

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The influences of the antitussive activity of glaucine were studied in 56 non-anaesthetized cats under normal and pathological conditions. Cough was induced by mechanical stimulation of the airways with a nylon fibre. The authors found that if glaucine was administered at a dose of 5.0, 7.5 and 10.0

On the sites of antitussive action of dl-glaucine phosphate.

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The sites of antitussive action of dl-1,2,9,10-tetramethoxy-6a,alpha-aporphine phosphate (dl-glaucine phosphate, DL-832) were studied. It was assumed from the following results that DL-832 acts on the cough center per se. a) When DL-832 was given by the routes leading to the brain stem such as the

Assessment of antitussive effects by citric acid threshold.

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The cough threshold to citric acid inhalation was measured in eight subjects by single inhalations of increasing concentrations of citric acid until a cough was consistently produced. The cough threshold was measured before and after 60 mg glaucine, 60 mg codeine and matched placebo on three

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