himatanthus obovatus/neoplasms

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Analysis of the action of Himatanthus drasticus in progression of urethane-induced lung cancer in mice.

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OBJECTIVE To evaluate the effect of janaguba in inhibiting the development of lung cancer in an experimental urethane-induced model. METHODS a total of 3mg/kg urethane was injected in 51 Balb-C mice aged 7-13 weeks of life. Janaguba was administered orally daily in two doses: 0.04 mL (Group 2, G2)

Antiproliferative effect of a traditional remedy, Himatanthus articulatus bark, on human cancer cell lines.

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BACKGROUND Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a tree occurring in the Amazon region. The local population uses its bark against to external tumors and cancer. OBJECTIVE Evaluated the antiproliferative activity of the crude extract and their fractions against human tumors

Leishmanicidal activity of Himatanthus sucuuba latex against Leishmania amazonensis.

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Himatanthus sucuuba (HsL) latex exhibited a potent leishmanicidal activity against intracellular amastigotes of Leishmania amazonensis, a causative agent of cutaneous leishmaniasis. HsL inhibited intracellular amastigote growth in a dose-dependent manner (IC(50)=15.7microg/mL). Moreover, HsL

Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice.

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BACKGROUND In Brazil, latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). METHODS HdCL was obtained in Crato-CE, Brazil. Qualitative

Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon.

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BACKGROUND Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria. OBJECTIVE To investigate the in vivo genotoxic and mutagenic potential of this plant, using the comet assay and the

Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel - Apocynaceae.

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BACKGROUND Himatanthus drasticus (Mart.) Plumel - Apocynaceae is a medicinal plant popularly known as Janaguba. Its bark and latex have been used by the public for cancer treatment, among other medicinal uses. However, there is almost no scientific research report on its medicinal

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus.

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Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The

Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo.

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Inflammatory bowel diseases (IBDs) are characterized by an inflammatory and oxidative stress condition in the intestinal tissue. In this study, we evaluated the effect of plumericin, one of the main bioactive components of Himatanthus sucuuba (Woodson) bark, on intestinal inflammation and oxidative

Promising medicinal plants for bioprospection in a Cerrado area of Chapada do Araripe, Northeastern Brazil.

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BACKGROUND Traditional medical systems represent an important source of knowledge about the use of biodiversity. Ethnobotanical and ethnopharmacological studies can encourage bioprospecting in the pursuit and selection of promising medicinal plants. This study investigated the diversity of medicinal

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