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hydroxamic acid/neoplasms
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Pagină 1 din 109 rezultate
Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
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This application is the national phase of international application PCT /GB98/00910 filed Mar. 25, 1998.
This invention relates to hydroxamic acid compounds and in particular to such compounds with a heterocyclicalkoxy substituent. This invention further relates to processes for preparing such
Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments
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This application is the U.S. National Phase of International Application PCT/EP2003/014171, filed 10 Dec. 2003, which designated the U.S. PCT/EP2003/014171 claims priority to Italian Application No. MI2003A000064 filed 17 Jan. 2003. The entire content of these applications are incorporated herein by
Oxazole hydroxamic acid derivatives and use thereof
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TECHNICAL FIELD
The present invention relates to an oxazole derivative useful for inhibition of histone deacetylase. More specifically, the present invention relates to an oxazole hydroxamic acid derivative useful for inhibition of histone deacetylase and use thereof.
BACKGROUND ART
Histones are
Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a .sctn.371 National State Application of PCT/CN2011/080213 filed Sep. 27, 2011, which claims priority to CN 201110278403.9 filed Sep. 19, 2011.
TECHNICAL FIELD OF THE INVENTION
The present invention relates to the organic chemistry and
Thiophene and benzothiophene hydroxamic acid derivatives
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FIELD OF THE INVENTION
The present invention relates to a novel class of hydroxamic acid derivatives having a benzothiophene or thiophene backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use
Hydroxamic acid-based bifunctional chelating compounds
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the field of linkers attaching ion-chelating groups to biologic molecules such as proteins or nucleic acids as well as tissues such as blood cells. More particularly, the present invention relates to hydroxamic
Hydroxamic acid derivatives as metalloproteinase inhibitors
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BACKGROUND OF THE INVENTION
Compounds which have the property of inhibiting the action of metalloproteinases involved in connective tissue breakdown such as collagenase, stromelysin and gelatinase (known as "matrix metalloproteinases", and herein referred to as MMPs) are thought to be potentially
Hydroxamic acid compounds as metalloprotease and TNF inhibitors
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FIELD OF THE INVENTION
The present invention relates to small molecules which inhibit matrix metalloproteinases, and the production of tumor necrosis factor (TNF), pharmaceutical preparations containing them and to their use as pharmaceutical agents.
BACKGROUND OF THE INVENTION
There is now a body
Arylsulfonamido-substituted hydroxamic acid derivatives
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The invention relates to arylsulfonamido-substituted hydroxamic acid derivatives, to processes and novel intermediates for their preparation, pharmaceutical compositions comprising said derivatives, pharmaceutical compositions comprising selective MMP2 inhibitors, the use of the hydroxamic acid
Arylsulfonamido-substituted hydroxamic acid derivatives
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This application is 371 of PCT/EP00/07641 filed on Aug. 7, 2000, which claim benif of United Kingdom 9918684.3 filed on Aug. 9, 1999.
The invention relates to arylsulfonamido-substituted hydroxamic acid derivatives, to processes and novel intermediates for their preparation, pharmaceutical
Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
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BACKGROUND OF THE INVENTION
Generally, the invention pertains to the field of pharmaceutical compounds and more specifically to the field of hydroxamic acid derivatives useful in the treatment of cancer. Cancer is the second leading cause of death in the United States and despite new breakthroughs
Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
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BACKGROUND OF THE INVENTION
Generally, the invention pertains to the field of pharmaceutical compounds and more specifically to the field of hydroxamic acid derivatives useful in the treatment of cancer. Cancer is the second leading cause of death in the United States and despite new breakthroughs
Hydroxamic acid derivatives with tricyclic substitution
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SUMMARY OF THE INVENTION
The present invention is concerned with hydroxamic acid derivatives with tricyclic substitution.
The hydroxamic acid derivatives provided by the present invention are compounds of the general formula ##STR2## wherein R.sup.1 represents cyclopropyl, cyclobutyl, cyclopentyl or
Hydroxamic acid derivatives with tricyclic substitution
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SUMMARY OF THE INVENTION
The present invention is concerned with hydroxamic acid derivatives with tricyclic substitution.
The hydroxamic acid derivatives provided by the present invention are compounds of the general formula ##STR2## wherein R.sup.1 represents cyclopropyl, cyclobutyl, cyclopentyl or
Hydroxamic acid derivatives with tricyclic substitution for treating degenerative joint diseases
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SUMMARY OF THE INVENTION
The present invention is concerned with hydroxamic acid derivatives with tricyclic substitution.
The hydroxamic acid derivatives provided by the present invention are compounds of the general formula ##STR2## wherein R.sup.1 represents cyclopropyl, cyclobutyl, cyclopentyl or
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