inosine/neoplasms

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Inosine pranobex-BAN increases the resistance to the challenge with cells or cell-free fluid from Yoshida ascites tumor.

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Inosine pranobex-BAN injected intraperitoneally at a daily dose of 500 mg/kg for 15 days into young Sprague-Dawley rats, beginning 24 hours after the implantation of Yoshida ascites tumor cells and the injection of cell-free ascites fluid from the same neoplasia, increased the resistance to the

Inhibition of 5-fluorouracil activation by oxipurinol in preparations of normal rat tissues and Jensen sarcoma: tumor-selective stimulation by inosine.

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The effects of inosine on oxipurinol-induced inhibition of 5-fluorouracil (FUra) activation were investigated in a transplantable rat tumor and three normal rat tissues in vitro. FUra activation directed toward RNA was assessed in preparations of small intestine and Jensen sarcoma by determining the

[Clinical and experimental study of 236 ED nutritional supportive therapy and inosine nutrition protection in postoperative gastric cancer patients].

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To confirm the effect of nutritional supportive therapy on cancer patients, 52 postoperative gastric cancer patients were selected and given 236 ED as nutritional therapy. Body weight and nutritional index before and after operation, complication, duration in hospital were compared in the

Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines.

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Inosine-5'-phosphate (IMP) dehydrogenase, a regulatory enzyme of guanine nucleotide biosynthesis, may play a role in cell proliferation and malignancy. To assess this role we examined IMP dehydrogenase expression in a series of human solid tumor tissues and tumor cell lines in comparison with their

Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells.

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Inosine 5-monophosphate dehydrogenase II, a key enzyme in the de novo synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor AVN944 on LNCaP,

Benzamide riboside, a recent inhibitor of inosine 5'-monophosphate dehydrogenase induces transferrin receptors in cancer cells.

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Benzamide riboside, a recently discovered inhibitor of IMP dehydrogenase (IMPDH) exhibits oncolytic activity. IMPDH is the key enzyme of de novo guanylate biosynthesis and was shown to be linked with proliferation. Therefore, IMPDH is a very good target for antitumor therapy. In order to be active,

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

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Mycophenolic acid (MPA), an inhibitor of IMP-dehydrogenase (IMPDH), is used worldwide in transplantation. Recently, numerous studies showed its importance in cancer treatment. Consequently, MPA entered clinical trials in advanced multiple myeloma patients. Suberoylanilide hydroxamic acid (SAHA), a

On the non-stoichiometry of the binding of Pt(II) anti-neoplastic agents to inosine 5'-monophosphate.

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Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS Ⅲ), and its challenge against Aeromonas hydrophila infection.

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The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS Ⅲ) (initial body weight: 7.48 g). Six diets were formulated

Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.

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Inosine monophosphate dehydrogenase (IMPDH) controls a key metabolic step in the regulation of cell growth and differentiation. This step is the NAD-dependent oxidation of inosine 5' monophosphate (IMP) to xanthosine 5' monophosphate, the rate-limiting step in the synthesis of the guanine

The intracellular accumulation of UDP-N-acetylhexosamines is concomitant with the inability of human colon cancer cells to differentiate.

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The relationship between the intracellular concentration of various nucleotides as measured by high-performance liquid chromatography analysis, and the differentiation of 2 human colon cancer cell lines was studied. HT-29 cells were induced to undergo both structural and functional enterocytic

Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.

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The feasibility of "early" thymidine and inosine protection of methotrexate (MTX) toxicity is evaluated in this paper. This approach is based on the proposition that the most vulnerable period for susceptible host cells to MTX toxicity is an interval following a pulse of MTX when the MTX

Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani.

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Carbocyclic inosine is a potent inhibitor for the growth of the promastigote form of Leishmania tropica and Leishmania donovani. In culture, the EC50 values of carbocyclic inosine are 8.3 X 10(-8) and 1.3 X 10(-7) M for the promastigotes of L. tropica and L. donovani, respectively. On the other

Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma A549 cell line using proteomics-based analysis.

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To screen cancer for specific autoantibodies, we applied the approach established by Brichory et al., who reported annexins I and II as specific antigens. Solubilized proteins from a cancer cell line (A549) were separated using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), followed

An ex vivo model for the study of tumor metabolism by nuclear magnetic resonance: characterization of the phosphorus-31 spectrum of the isolated perfused Morris hepatoma 7777.

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We have developed an isolated perfused tumor model to study the metabolism of solid tumors by nuclear magnetic resonance spectroscopy. Morris hepatomas (7777) were implanted in the inguinal region of Buffalo rats, such that they developed an isolated blood supply. These tumors were perfused with a

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