kernicterus/albumină

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Kernicterus at low levels of serum bilirubin: the impact of bilirubin albumin-binding capacity. A 10-year retrospective survey.

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A retrospective survey of neonatal post-mortems over a 10-year period was made to establish the incidence of kernicterus and the associated laboratory abnormalities. Cases with evidence of kernicterus without hyperbilirubinaemia were found to have significantly lower reserve albumin-binding capacity

Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates.

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We performed this study to summarize the recent epidemiological characteristics of bilirubin encephalopathy and assess the role of total bilirubin-albumin ratio in the bilirubin encephalopathy. We retrospectively collected clinical data of 669 neonates with hyperbilirubinemia from the First

Serum bilirubin and bilirubin/albumin ratio as predictors of bilirubin encephalopathy.

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OBJECTIVE Bilirubin/albumin ratio (B/A) may provide a better estimate of free bilirubin than total serum bilirubin (TSB), thus improving identification of newborns at risk for bilirubin encephalopathy. The objective of the study was to identify thresholds and compare specificities of TSB and B/A in

The binding capacity of human albumin for bilirubin and its significance in the significance in the pathogenesis of kernicterus.

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Microdetermination of unbound bilirubin in sera. Application to the prevention of kernicterus by estimating the bilirubin-binding capacity of serum albumin.

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Bilirubin-albumin binding and a possible mechanism of kernicterus.

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Bilirubin, albumin, and the risk of kernicterus.

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Studies in kernicterus. II. The determination of the saturation of serum albumin with bilirubin.

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Serum albumin reserve PSP dye binding capacity in infants with kernicterus.

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[The problem of the prophylaxis of bilirubin encephalopathy in the premature infant. Experiences with transfusions of human serum albumin].

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The effects of hypoxanthine, xanthine oxidase and hyperoxia on the accumulation of bilirubin and albumin in young rat brain.

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Hyperoxia has been suggested as a risk factor for kernicterus. The toxicity of hyperoxia may be mediated by free radicals. We investigated the effects of free radicals, formed by the hypoxanthine/xanthine oxidase system, with and without additional hyperoxia, on the accumulation of bilirubin and

Effect of ibuprofen on bilirubin-albumin binding.

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Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn

Establishment of an albumin-deficient and jaundiced strain of rats.

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An albumin deficient and jaundiced rat (AJR) strain was established from crosses between Albumin-Deficient rats (NAR) and jaundiced Gunn rats. AJRs have a double homozygous mutant trait (alb/alb, j/j), and systemic jaundice and various neurological signs are observed 5--7 days after birth,

Increase of plasma nonesterified fatty acid concentration and decrease of albumin binding affinity after intravenous injection of glycocholate-lecithin mixed micelles.

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Lipophilic drugs intended for intravenous use can be solubilized by mixed-micellar systems containing glycoholic acid and lecithin (MM). Our present studies determined the influence of such MM preparations on albumin binding of monoacetyldiaminodiphenyl sulfone (MADDS), a deputy ligand for

The use of critical levels of birth weight and "free bilirubin" as an approach for prevention of kernicterus.

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Free bilirubin (FB) and total bilirubin (TB) were determined in 154 samples of blood taken from 112 jaundiced newborns: 51 prematures without hemolysis (19 of these with RDS); 26 full terms presenting ABO incompatibility; 35 newborns (both prematures and full terms) presenting rhesus

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