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Transcatheter arterial embolization using poly-L-lactic acid microspheres.

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OBJECTIVE To assess the use of poly-L-lactic acid (PLLA) microspheres as an embolic material in transcatheter arterial embolization (TAE). METHODS Between December 1993 and August 1995, eight patients [dural arteriovenous fistula (AVF) (n = 1), acute hemoptysis (n = 7)] underwent nine TAE procedures

L-Lactic acid: a mosquito attractant isolated from humans.

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L-Lactic acid was the major component in material isolated from humans that was active as an attractant for female yellow fever mosquitoes, Aedes aegypti (L.). The L(+)-isomer was several times as attractive as the D-isomer. Good correlation was found between the attractiveness of an individual to

Paclitaxel Magnetic Core⁻Shell Nanoparticles Based on Poly(lactic acid) Semitelechelic Novel Block Copolymers for Combined Hyperthermia and Chemotherapy Treatment of Cancer.

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Magnetic hybrid inorganic/organic nanocarriers are promising alternatives for targeted cancer treatment. The present study evaluates the preparation of manganese ferrite magnetic nanoparticles (MnFe₂O₄ MNPs) encapsulated within Paclitaxel (PTX) loaded thioether-containing

Thermo-triggered drug release from actively targeting polymer micelles.

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How to deliver the drug to the target area at the right time and at the right concentration is still a challenge in cancer therapy. In this study, we present a facile strategy to control drug release by precisely controlling the thermo-sensitivity of the nanocarriers to the variation of

Challenges in the Diagnosis of Leak After Sleeve Gastrectomy: Clinical Presentation, Laboratory, and Radiological Findings

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Background: The presentation of leak after laparoscopic sleeve gastrectomy (LSG) is variable. A missed or delayed diagnosis can lead to severe consequences. This study presents our experience: the clinical presentations, laboratory, and

Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.

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Triggering shape-memory functionality under clinical hyperthermia temperatures could enable the control and actuation of shape-memory systems in clinical practice. For this purpose, we developed light-inducible shape-memory microparticles composed of a poly(d,l-lactic acid) (PDLLA) matrix

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.

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Lonidamine (LND) is an anti-tumour drug particularly effective at selectively sensitizing tumours to chemotherapy, hyperthermia and radiotherapy, although its precise mode of action remains unclear. It has been reported to perturb the bioenergetics of cells by inhibiting glycolysis and mitochondrial

Mechanism of antineoplastic activity of lonidamine.

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Lonidamine (LND) was initially introduced as an antispermatogenic agent. It was later found to have anticancer activity sensitizing tumors to chemo-, radio-, and photodynamic-therapy and hyperthermia. Although the mechanism of action remained unclear, LND treatment has been known to target metabolic

2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy.

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One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of a 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared

Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy.

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Carbon nanotubes are effective thermal generators by absorbing near-infrared radiation (NIR). In this study, multiwalled carbon nanotubes (MWCNTs) and doxorubicin (DOX) were successfully electrospun into the poly-l-lactic acid (PLLA) nanofibers. It is confirmed that NIR radiation could not only

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