The invention relates to the diagnosis and treatment of diseases, including inflammatory disorders, proliferative disorders and autoimmune diseases. The invention provides, and involves the use of, antibody molecules that bind: i) lysozyme, ii) neutrophil elastase, iii) tissue inhibitor of metalloproteinase-1 (TIMP-1), or iv) the D domain of Tenascin-C. The invention also relates to the use of antibody molecules that bind v) the IIICS isoform of fibronectin, vi) the Extra Domain-B (ED-B) of fibronectin, vii) matrix-metalloproteinase 3 (MMP3), or viii) the A1 domain of tenascin-C in the diagnosis and treatment of inflammatory disorders such as inflammatory bowel disease.

PHILOGEN S.P.A.

Antibodies for treatment and diagnosis of inflammatory bowel disease

Methods and compositions for treating myocardial dysfunction or inflammation are described. The methods of the invention involve administering an agent that can inhibit lysozyme to an animal in need thereof. Preferred lysozyme inhibitors include TAC and chitobiose.

lysozyme/inflamație

Antibodies for treatment and diagnosis of inflammatory bowel disease

Methods of treating inflammation

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