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mandelic acid/obezitate
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Upscale production of (R)-mandelic acid with a stereospecific nitrilase in an aqueous system.
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(R)-Mandelic acid (R-MA) is a key precursor for the synthesis of semi-synthetic penicillin, cephalosporin, anti-obesity drugs, antitumor agents, and chiral resolving agents for the resolution of racemic alcohols and amines. In this study, an enzymatic method for the large-scale production of R-MA by
Free 3-methoxy-4-hydroxyphenylglycol (MHPG) in human urine: metabolic routes, biochemical and clinical significance in healthy and obese children.
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Conjugated MHPG is an indicator of the adrenergic tonus having clinical use in the follow-up of affective disorders, arterial hypotension, anorexia nervosa and recently of obesity. Little is known about the significance of the unconjugated, free MHPG in various body fluids. Nineteen healthy and 38
Decrease of urinary levels of adrenergic metabolites including conjugated MHPG after a short term course of diethylpropion in obese children fed a mixed, low-calorie diet.
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A short term course (8-11 days) of diethylpropion 50 mg a day was administered to 12 obese children of both sexes fed a mixed low calorie diet containing about 1000 calories/day. A group of 10 obese children received the same diet and no medication. The sex-distribution was similar in both groups as
Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.
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OBJECTIVE
Metabolomics may unravel global metabolic changes in response to environmental exposures and identify important biological pathways involved in the pathophysiology of childhood obesity. Phthalate has been considered an obesogen and contributing to overweight and obesity in children. The
The effect of modified fasting on blood pressure and sympathetic activity: a correlation?
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The effect of a low calorie diet (200 kcal/0.8 MJ) composed of 50 per cent glucose and 50 per cent protein was studied on blood pressure and sympathetic activity in eight normotensive obese subjects. The study lasted 21 days; during the first seven days (period I) a weight maintaining diet was
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