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Inhibition of autophagy augments the anticancer activity of α-mangostin in chronic myeloid leukemia cells.

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Natural products possessing anticancer activity have been extensively studied because of their low toxicity and potential effect. α-Mangostin, a component of Garcinia mangostana Linn, is a xanthone derivative shown to have antioxidant and antitumor properties. This study was carried out to

Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo.

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BACKGROUND Beta-mangostin (BM) is a xanthone-type of natural compound isolated from Cratoxylum arborescens. This study aimed to examine the apoptosis mechanisms induced by BM in a murine monomyelocytic cell line (WEHI-3) in vitro and in vivo. METHODS A WEHI-3 cell line was used to evaluate the

Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.

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Our previous study has shown that alpha-mangostin, a xanthone from the pericarps of mangosteen, induces caspase-3-dependent apoptosis in HL60 cells. In the current study, we investigated the mechanism of apoptosis induced by alpha-mangostin in HL60 cells. Alpha-mangostin-treated HL60 cells

Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy.

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Mangostin (MAG), a kind of xanthone widely used in diet and medicine, has antioxidant, anti-inflammatory, antimicrobial, and anticancer activities. On account of its antioxidant activity, MAG might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive

Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.

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We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction

Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G0/G1 cell-cycle arrest.

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Xanthones are phytochemical compounds found in a number of fruits and vegetables. Characteristically, they are noted to be made of diverse properties based on their biological, biochemical, and pharmacological actions. Accordingly, the apoptosis mechanisms induced by beta-mangostin, a xanthone

Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

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Mangostin, Garcinia mangostana L. is used as a traditional medicine in southeast Asia for inflammatory and septic ailments. Hitherto we indicated the anticancer activity induced by xanthones such as alpha-, beta-, and gamma-mangostin which were major constituents of the pericarp of mangosteen

Xanthones from the seeds of Allanblackia monticola and their apoptotic and antiproliferative activities.

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Phytochemical investigations of the seeds of ALLANBLACKIA MONTICOLA have led to the isolation and characterization of one new xanthone derivative, named allanxanthone E ( 1), together with seven known compounds, including five xanthones, 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone ( 2),

Two new pyranoxanthones from the stem bark of Calophyllum pseudomolle P.F. Stevens

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Two new pyranoxanthones, calotetrapterins D (1) and E (2), were isolated from the stem bark of Calophyllum pseudomolle P.F. Stevens along with α-mangostin (3). The structures of compounds 1-2 were determined based on 1D NMR (¹H, ¹³C)

Natural products as LSD1 inhibitors for cancer therapy

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Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new

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