mikanolide/mikania

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Mikanolide from Jamaican Mikania micrantha.

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Mikanolide [systematic names: 1,10:2,3-diepoxy-6,8-dihydroxy-11-vinylgermacr-4-ene 12,14-di-gamma-lactone and 7,10a-dimethyl-1a,1b,2a,6a,7,9a,10,10a-octahydro-4H-6,3-methenofuro[3,2-c]bisoxireno[f,h]oxacycloundecin-4,8(6H)-dione], C(15)H(14)O(6), derived from a variety of Mikania micrantha growing

The antibacterial activities of mikanolide and its derivatives.

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OBJECTIVE The sesquiterpene, mikanolide, was found to possess antibacterial activity. As a result, a structure-activity relationship study was carried out on mikanolide and eleven of its derivatives. METHODS Mikanolide and two of its derivatives were isolated from organic extract of Mikania

Germacra-1,10Z,4E-dien-12,8alpha-olides from Mikania micrantha.

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The aerial parts of MIKANIA MICRANTHA from a collection in Paraguay gave, in addition to mikanolide, deoxymikanolide, and miscandenin, five new germacranolides all derived from 14,15-dihydroxygermacra-1(10) E,4 Z-dien-12,8alpha-olide.

Investigation of plants used in Jamaican folk medicine for anti-bacterial activity.

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We have started a systematic scientific study of folklore medicinal plants currently used as alternative medicine in Jamaican society. In this initial study, extracts of plants widely used by the islanders are studied for antibacterial activity against five common pathogens; Streptococcus group A,

Analgesic sesquiterpene dilactone from Mikania cordata.

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The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show

Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp.

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Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4%

Allelopathic activity studies of Mikania scandens.

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Preliminary investigation of a number of plant extracts for allelopathic activity using seed germination inhibition bioassay showed a promising activity of the water extract of the aerial parts of Mikania scandens. Activity-guided fractionation of the M. scandens extract led to the isolation of the

Antimicrobial constituents of the leaves of Mikania micrantha H. B. K.

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BACKGROUND To isolate plant-derived compounds with antimicrobial activity from the leaves of Mikania micrantha, to determine the compounds configuration, and to evaluate their antimicrobial activity against eight plant pathogenic fungi (Exserohilum turcicum, Colletotrichum lagenarium,

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