mucic acid/neoplasms

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Nanoparticles containing a combination of a drug and an antibody for the treatment of breast cancer brain metastases.

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In women with human epidermal growth factor 2 (HER2)-positive breast cancer, improved control of systemic disease with new therapies has unmasked brain metastases that historically would have remained clinically silent. Efficacy of therapeutic agents against brain metastases is limited by their

Composition and biological activities of hydrolyzable tannins of fruits of Phyllanthus emblica.

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Fruits of emblic leafflower have been used as food and traditional medicine in Asia. A wide range of biological activities have been shown in modern research suggesting potential of the fruits as healthy food and raw material for bioactive ingredients of food. Hydrolyzable tannins are among the

Single-antibody, targeted nanoparticle delivery of camptothecin.

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We have developed a new method for assembling targeted nanoparticles that utilizes the complexation between targeting agents that contain boronic acids and polymer-drug conjugates that possess diols. Here, we report the first in vivo, antitumor results of a nanoparticle formed via this new assembly

Biological Activities of Phenolics from the Fruits of Phyllanthus emblica Linn. (Euphorbiaceae).

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Seven phenolic compounds, 1 - 7, including a new organic acid gallate, mucic acid 1-ethyl 6-methyl ester 2-O-gallate (7), were isolated from the MeOH extract of the fruits of Phyllanthus emblica L. (Euphorbiaceae). The structures were elucidated on the basis of extensive spectroscopic analysis and

Targeted nanoparticles assembled via complexation of boronic-acid-containing targeting moieties to diol-containing polymers.

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The delivery of therapeutics via nanoscaled vehicles for solid cancer treatment can be enhanced by the incorporation of a targeting capability. Here, we describe a new method for assembling a targeted nanoparticle that utilizes the reversible covalent complexation between boronic acids and diols to

Toxicological Evaluation of Emblica officinalis Fruit Extract and its Anti-inflammatory and Free Radical Scavenging Properties.

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BACKGROUND Emblica officinalis (Euphorbiaceae), popularly known as Indian gooseberry or "Amla" in India, is used in Ayurveda as "rejuvenating herb" since ancient times. OBJECTIVE This study was carried out to estimate toxicity, anti-inflammatory, and antioxidative activities of the methanolic

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