mycosis fungoides/adenozină

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Adenosine deaminase activity in sera of patients with psoriasis, mycosis fungoides and adult T cell leukemia.

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Adenosine deaminase activities in sera were measured in 18 psoriatic patients, 8 mycosis fungoides patients, and 9 patients with adult T cell leukemia. Adenosine deaminase activity in the sera of the psoriatic patients showed no significant increase. An elevated adenosine deaminase activity was

Clinical significance of serum adenosine deaminase activity in patients with mycosis fungoides.

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Adenosine deaminase is one of the key enzymes in purine nucleotide degradation. This enzyme exists in most of the human tissues and the activity is high in lymphatic tissues, especially in T lymphocytes. Elevated adenosine deaminase activity in T cell leukemia has been reported, and its inhibitor,

Normal serum adenosine deaminase activity in mycosis fungoides.

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Systemic therapy of cutaneous T-cell lymphomas (mycosis fungoides and the Sézary syndrome).

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OBJECTIVE To review recent studies of systemic therapy for mycosis fungoides and the Sézary syndrome (cutaneous T-cell lymphomas). METHODS English-language articles indexed in MEDLINE from 1988 through 1994. METHODS All therapeutic studies were selected. METHODS The data were abstracted without

[Identification of Langerhans cells in dermatology].

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This paper describes our own findings on the role of Langerhans' cells in dermatology and discusses literature data on their detection in seven different dermatoses. The skin is an integral part of immune system. During the past 30 years, increasing evidence has been accumulated that the skin

Overview of cutaneous T-cell lymphoma: prognostic factors and novel therapeutic approaches.

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The cutaneous T-cell lymphomas (CTCL) comprise a heterogeneous group of entities. The WHO classification distinguishes indolent low-risk entities, including mycosis fungoides/Sézary syndrome (MF/SS), from aggressive entities, including peripheral T-cell lymphoma and its variants and HTLV-1

Deoxycoformycin: an active new drug for indolent lymphomas and hairy cell leukemia.

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Promising results in the treatment of indolent lymphomas have been reported with the use of 2'deoxycoformycin. This antimetabolite, an adenosine deaminase inhibitor, also shows particular efficacy in hairy cell leukemia. Of 65 patients treated to date, 44 have achieved complete and lasting remission

Pentostatin treatment of cutaneous T-cell lymphoma.

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Mycosis fungoides is an indolent primary cutaneous T-cell lymphoma (CTCL) that usually progresses from localized skin lesions to systemic disease. Sézary syndrome is a distinct variant characterized by generalized erythroderma and circulating cerebriform cells in the peripheral blood. The malignant

Clinical pharmacology of deoxycoformycin.

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Deoxycoformycin (DCF) is an inhibitor of adenosine deaminase (ADA). Twenty-one courses of DCF were administered to 13 patients ranging in age from 15 to 78 yr. Eight patients had T-cell disorders, and five patients had non-T-cell malignancies. The i.v. bolus dose was escalated from 5 to 30 mg/sq

2'-Deoxycoformycin (pentostatin) for lymphoid malignancies. Rational development of an active new drug.

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A new antimetabolite, 2'-deoxycoformycin (pentostatin), has striking antitumor activity in several lymphoid neoplasms. Isolated from cultured soil organisms, this purine analogue is a potent inhibitor of adenosine deaminase (ADA), and is thus selectively toxic to lymphocytes. Early clinical trials

Efficacy of methotrexate as anti-inflammatory and anti-proliferative drug in dermatology: Three case reports.

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Methotrexate (MTX) is a folic acid analog with anti-proliferative (anti-neoplastic, cytotoxic), immunosuppressive and anti-inflammatory properties, which has been used in the treatment of various cutaneous disorders, such as psoriasis, keratoacanthoma, pityriasis rubra pilaris, atopic dermatitis,

Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies.

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Fludarabine phosphate is the 2-fluoro, 5'-monophosphate derivative of vidarabine (ara-A) with the advantages of resistance to deamination by adenosine deaminase (ADA) and improved solubility. The mechanism of cytotoxic action of the compound appears to involve metabolic conversion to the active

An investigation of 2'-deoxycoformycin in the treatment of cutaneous T-cell lymphoma.

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We have investigated the use of 2'-deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase (ADA), in the treatment of 4 patients with advanced mycosis fungoides (MF). Since DCF has demonstrated an adverse effect in vitro and in vivo on the survival of leukemia T-cell lines, it appeared

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