oenanthotoxin/seizures

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Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons.

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OBJECTIVE Oenanthotoxin (OETX), a polyacetylenic alcohol from plants of the genus Oenanthe, has recently been identified as potent inhibitor of GABA-evoked currents. However, the effects of OETX on the inhibitory postsynaptic currents (IPSCs), as well as the pharmacological mechanism(s) underlying

Block of ionic and gating currents in node of Ranvier with oenanthotoxin.

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Oenanthotoxin (OETX) is known to induce convulsions and epileptic spikes in rat. It is shown that OETX reversibly blocks the action potential and the sodium, potassium and gating currents in frog myelinated nerve fibres. These observations suggest that the block of ionic currents by OETX is due to

Changes in [Ca2+]0, [K+]0 and neuronal activity during oenanthotoxin-induced epilepsy in cat sensorimotor cortex.

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Effects of the convulsant drug oenanthotoxin on field potentials, neuronal discharges and extracellular free Ca2+ and K+ concentrations were studied in the sensorimotor cortex of cats. Fifteen to 20 min after topical OETX application spike activity developed (surface negative, deeper layers

[Convulsions induced by enanthotoxin in the rat: correlation between electrophysiological modifications and clinical signs].

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When injected intraperitoneally in the Rat, oenanthotoxin induces localised myoclonic jerks and generalised tonic-clonic seizures. Electrocorticographic recordings reveal typical epileptic spikes. Correlations between electromyographic bursts, electrocorticographic events and subcortical activities

Toxic polyacetylenes in the genus Bupleurum (Apiaceae) - Distribution, toxicity, molecular mechanism and analysis.

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BACKGROUND The genus Bupleurum includes approximately 200 species that are widely distributed in the Northern Hemisphere, Eurasia and North Africa. Certain species of this genus have long been used as antiphlogistic, antipyretic and analgesic agents in traditional folk medicine. As described in the

Hemlock water dropwort poisoning.

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Severe plant poisoning is relatively uncommon in adults. We report two adults who ingested hemlock water dropwort roots, having mistaken them for wild parsnip. One developed prolonged convulsions, severe metabolic acidosis and respiratory distress requiring mechanical ventilation. The

[Diminution of the extracellular concentration of calcium ions during focal epileptic crisis induced by enanthotoxin in the cat cortex].

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OEnanthotoxin applied locally onto the Cat cortex produced a long-lasting epileptic focus. The basic cortical level of extracellular calcium concentration ([Ca2+]e) was decreased before the actual onset of paroxysmal discharges. In the active focus the [Ca2+]e decrease induced by a cortical or a

Poisoning due to water hemlock.

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BACKGROUND Water hemlock, which encompasses a range of species divided across two genera (Cicuta and Oenanthe), are regarded as being among the most poisonous plants both in North America and in the United Kingdom. Despite their toxicity, the literature consists almost entirely of case

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