optic neuritis/nicotine

The vasopressin test gave pathological results in 12 cases of optic atrophy and normal results in three cases. One of the patients with a pathological response had Leber's disease and three had tobacco-alcholic amblyopia, while in the rest the optic atrophy was of uncertain origin. In the cases with

Role of vegetarianism, smoking, and hydroxocobalamin in optic neuritis.

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Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the

Toxicological and clinical aspects of cyanide metabolism.

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This contribution deals with the occurrence of cyanide and its biological pathways in the body. Especially possibilities of detoxification are pointed out. Intoxications are caused by acute and chronical cyanide uptake. Tobacco amblyopia, retrobulbar neuritis in pernicious anaemia, Leber's optic

[The history of neuro-ophthalmology in Edinburgh. Part I].

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The Edinburgh Medical School occupies a unique position in the history of medicine. It gave the three famous clinicians and scientists who significantly developed the fundamentals of neuro-ophthalmology: Sir Charles Bell, Douglas Argyll Robertson and Harry Moss Traquair. Sir Charles Bell (1774-1842)

High incidence of visual recovery among four Japanese patients with Leber's hereditary optic neuropathy with the 14484 mutation.

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The 14484 mutation in the ND6 gene of mitochondrial DNA (mtDNA) is a genetic mutation associated with Leber's hereditary optic neuropathy (LHON) in Caucasian patients who show a high incidence of visual recovery. We evaluated four Japanese patients with LHON associated with the 14484 mutation who

Spectral threshold: measurement and clinical applications.

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Photopic spectral sensitivities for a foveal target on a white background are measured for 18 normal eyes, and the results are explained in terms of the function of retinal ganglion cells. Averaged results for diseases such as glaucoma, optic atrophy, tobacco amblyopia, and retrobulbar neuritis are

[Diagnostic error in Leber's optic neuropathy. Value of clinical and molecular genetic studies].

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BACKGROUND Leber's hereditary optic neuropathy is associated with point mutations in the mitochondrial DNA (mtDNA) that appear to be pathogenic for this disease. These mutations affect nucleotide positions 3460, 11,778 and 14,484. METHODS We reviewed the clinical and molecular genetic

[Chiasmal syndromes (author's transl)].

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Chiasmal syndromes (characterized by bitemporal field defects, decrease of vision and simple optic atrophy) are not only caused by tumors within the chiasmal region, but also occur in inflammatory, toxic, demyelinizing and hereditary-atrophic processes of the chiasm, respectively the optic nerve. In

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