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GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice.

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OBJECTIVE Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP-1 receptor (GLP-1R) agonist exenatide on sperm quality in high-fat diet (HFD)-induced obese mice. METHODS After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either

[Inguinal hernia in the elderly. Indications, techniques, results].

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OBJECTIVE Inguinal hernia in the elderly is a quite common problem in general surgery. Surgical treatment must be aware of the cardiovascular and respiratory pathology these patients are often affected by and, on the other side, the goal of surgery is a quick functional recovery after the operation

International web survey shows high prevalence of symptomatic testosterone deficiency in men.

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BACKGROUND Though the clinical significance of testosterone deficiency is becoming increasingly apparent, its prevalence in the general population remains unrecognised. A large web-based survey was undertaken over 3 years to study the scale of this missed diagnosis. METHODS An online questionnaire

Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells.

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Folliculostellate cell gap junctions establish a network for the transmission of information within the anterior pituitary. Connexins make up gap junction channels. Changes in connexin (Cx) turnover modify gap junction-mediated intercellular communication. We have reported that cytokines and

Cytokines and male infertility.

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Many male infertility cases have no apparent cause, being characterized as idiopathic. Both inflammation and obesity have long been associated with infertility. On one hand, inflammation, such as orchitis and male accessory gland infections (MAGIs), are regulated by inflammatory cytokines. The

Long-term health effects among testicular cancer survivors.

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Testicular cancer is diagnosed at a young age and survival rates are high; thus, the long-term effects of cancer treatment need to be assessed. Our objectives are to estimate the incidence rates and determinants of late effects in testicular cancer survivors. We conducted a population-based cohort

Epidemiology of male breast cancer.

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Breast cancer in men is a rare disease, accounting for approximately 1% of all breast cancer cases. Although the epidemiologic literature regarding female breast cancer is extensive, relatively little is known about the etiology of male breast cancer (MBC). This review is intended to summarize the

Sleep disturbances and semen quality in an Italian cross sectional study.

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BACKGROUND In order to obtain information about the relationship between sleep disturbances and sperm parameters, we analyzed data from a study conducted in a Italian Fertility Clinic, in men of couples seeking help for infertility. METHODS Male partners with or without a medical history of

Breast cancer in men: risk factors with hormonal implications.

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Cases included in a population-based case-control study of breast cancer in men were recruited from 10 geographic areas of the United States from 1983 to 1986. Controls, matched to cases on age and geographic area, were selected by random digit dialing for men under age 65 years and from Health Care

Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts.

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What are the primary causes of severe male factor infertility? Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. There are few large-scale

Etiologic factors for male breast cancer in the U.S. Veterans Affairs medical care system database.

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The etiology of male breast cancer is largely unknown, reflecting its relative rarity. Although a number of previous studies have suggested relationships with a variety of medical conditions, the results have largely derived from case-control studies and may reflect recall biases. Within the large

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