pancytopenia/glutation

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[Pancytopenias with erythrocyte pyruvate kinase- and glutathione reductase deficiencies].

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Hemolytic anemia and pancytopenia in glutathione reductase deficiency: further experience with riboflavin.

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[Glutathione reductase and thriosephosphate isomerase deficiency in erythrocytes and thrombocytes in pancytopenia (Estren-Damashek type)].

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[Transient pyruvate kinase- and glutathione reductase deficiency of erythrocytes in chronic idiopathic infantile pancytopenia].

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[Cytogenetic and cytologic findings in enzymopenic panmyelopathies and pancytopenias. Familial myelopathy of Fanconi, glutathione-reductase deficiency anemia and megaloblastic B12 deficiency anemia].

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Oxidative damage of erythrocytes: a possible mechanism for premature hemolysis in experimental visceral leishmaniasis in hamsters.

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Visceral leishmaniasis is accompanied by severe anemia and pancytopenia. Reactive oxygen species are known to contribute to the pathogenesis of several red blood cell (RBCs) disorders. The present study reveals the extent of oxidative stress and the efficacy of the primary antioxidant system in

[Bone marrow morphology and various hemolytic markers in growing rats with alimentary lead deficiency].

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The effects of an alimentary lead deficiency on bone marrow morphology and several laboratory parameters of hemolysis were examined in two growth- and one generation-experiments with female Sprague Dawley rats. The animals were fed a semisynthetic casein-based diet supplemented with 0 ppb up to 800

Quinones as toxic metabolites of benzene.

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Occupational exposure to benzene has long been associated with toxicity to the blood and bone marrow, including lymphocytopenia, pancytopenia, aplastic anemia, acute myelogenous leukemia, and possibly lymphoma. A variety of studies have established that benzene itself is not the toxic species but

Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS).

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BACKGROUND Ezatiostat, a glutathione S-transferase P1-1 inhibitor, promotes the maturation of hematopoietic progenitors and induces apoptosis in cancer cells. RESULTS Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500

Oxidation of hydroquinone by copper: chemical mechanism and biological effects.

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Exposure of humans and experimental animals to benzene has been shown to result in hematotoxicity such as pancytopenia, aplastic anemia, and leukemia. The oxidative activation of the benzene metabolite, hydroquinone (HQ), in the bone marrow to the electrophilic benzoquinone (BQ) has been suggested

Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice.

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Benzene is an important industrial chemical. At certain levels, benzene has been found to produce aplastic anemia, pancytopenia, myeloblastic anemia and genotoxic effects in humans. Metabolism by cytochrome P450 monooxygenases and myeloperoxidase to hydroquinone, phenol, and other metabolites

Aplastic anemia in a professional musician exposed to instrument polish.

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Chemicals are known to cause toxin-induced aplastic anemia. However, some chemicals documented in only a few cases to possess only a possibility of toxic potential may also be responsible for the development of aplastic anemia. This report presents a case of a string musician with bone marrow

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