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Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals.

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The aim of this study was to compare the diagnostic performances for the detection of myocardial ischemia of 82-Rb-PET-MPS and 99m-Tc-SPECT-MPS in overweight individuals and women.Men with BMI ≥ 25 and women referred for MPS were considered for inclusion.

Functionally abnormal Na+-K+ pump in erythrocytes of a morbidly obese patient.

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The Na(+)-K(+) pump in the erythrocytes of a mordibly obese patient shows a unique constellation of functional abnormalities. The number of pump units, measured by [(3)H]ouabain binding to intact cells, as well as the enzymatic activity of the (Na(+)-K(+))-dependent ATPase in erythrocyte membranes

Red-cell sodium-potassium pump and sodium-lithium countertransport in human obesity. Re-evaluation of the methods and association in a Finnish population.

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Specific ouabain binding, active rubidium transport and sodium-lithium countertransport were studied in erythrocytes of 55 normal weight (BMI less than 27), 10 overweight (27 less than or equal to BMI less than 32) and 27 obese (BMI greater than or equal to 32) Finnish subjects after re-examination

Lymphocyte (Na,K) ATPase-dependent 86Rb+ uptake in human obesity.

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Sodium and potassium ion-activated adenosinetriphosphatase (EC number 3.6.1.3) activity, measured as the uptake of 86 rubidium (an analogue of potassium) was determined on peripheral lymphocytes isolated from 20 normotensive obese subjects and 20 normal weight subjects. No difference in the total

Reduced activity of the red-cell sodium-potassium pump in human obesity.

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Looking for evidence of reduced energy use in the cells of obese persons, we measured the numbers of sodium-potassium-pump units in erythrocytes from a group of 21 obese human subjects and found them to be reduced by 22 per cent as compared with those of nonobese controls (P <0.001). The

Erythrocyte cation transport in obesity, hypertension, and during antihypertensive drug therapy.

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The number and activity of erythrocyte ATPase-dependent sodium-potassium pump units were increased in obese subjects (p = 0.02). No link was observed between the number or activity of the pump units and hypertension. The ouabain-insensitive rubidium (i.e. potassium) transport was not associated with

Clinical performance of Rb-82 myocardial perfusion PET and Tc-99m-based SPECT in patients with extreme obesity.

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BACKGROUND We evaluated the performance of stress imaging with technetium-99m-labeled tetrofosmin single-photon emission computed tomography (SPECT) and rubidium-82 positron emission tomography (PET) in patients with extreme obesity, defined as body mass index ≥40 kg/m2. METHODS We identified

Prognostic value of PET myocardial perfusion imaging in obese patients.

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OBJECTIVE This study sought to determine and compare the prognostic and incremental value of positron emission tomography (PET) in normal, overweight, and obese patients. BACKGROUND Cardiac rubidium 82 (Rb-82) PET is increasingly being used for myocardial perfusion imaging (MPI). A strength of PET

Story of Rubidium-82 and Advantages for Myocardial Perfusion PET Imaging.

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Rubidium-82 has a long story, starting in 1954. After preclinical studies in dogs showing that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow (MBF), clinical studies were performed in the 80s leading to an approval in the USA in 1989. From that time,

The impact of prompt gamma compensation on myocardial blood flow measurements with rubidium-82 dynamic PET.

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BACKGROUND Rubidium-82 myocardial perfusion imaging is a well-established technique for assessing myocardial ischemia. With continuing interest on myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurements, there is a requirement to fully appreciate the impact of technical aspects of

What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography?

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OBJECTIVE The objective was to determine the prognostic value of rubidium-82 (82Rb) positron emission tomography (PET) myocardial perfusion imaging (MPI). BACKGROUND 82Rb PET MPI accurately diagnoses coronary artery disease (CAD). However, there are limited data evaluating its prognostic

Effects of zinc on the content of chemical elements in the liver of rats during early stages of obesity.

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In rats with slight alimentary obesity, the content of chemical elements in the liver did not differ from normal, but the correlations between these elements were changed, which attested to metabolic disorders. Additional zinc dose administered to rats receiving lipid-rich rations did not affect

Effect of zinc on the content of chemical elements in the lung tissue during obesity in the experiment.

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We found no deviations from normalcy in the content of chemical elements (K, Ca, Mn, Fe, Cu, Zn, Se, Br, Rb, and Sr) in the lungs of rats with mild alimentary obesity, but revealed redistribution of correlations between the elements indicating impaired metabolism in this organ. Zinc supplementation

Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease.

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BACKGROUND Coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography of the LAD is used to assess microvascular function but validation studies in clinical settings are lacking. We aimed to assess feasibility, reproducibility and agreement with myocardial flow reserve

Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease.

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OBJECTIVE Our objective was to determine the accuracy of rubidium-82 myocardial perfusion positron emission tomography-computed tomography (PET-CT) imaging for detecting obstructive coronary artery disease (CAD). BACKGROUND Hybrid PET-CT is a new noninvasive imaging modality for evaluating patients

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