saikosaponin/seizures

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[Effect of saikosaponins on epileptic seizure and EEG in pentetrazole-induced chronic kindling rats].

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OBJECTIVE To study the effect of saikosaponins, the active ingredients of Bupleurum chinense DC, on epileptic seizure and EEG of pentetrazole (PTZ)-induced chronic kindling rats. METHODS Forty-eight healthy Sprague-Dawley rats were randomly divided into 6 equal groups, namely the blank control

Saikosaponin a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons.

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Saikosaponin a (SSa), a main constituent of the Chinese herb Bupleurum chinense DC., has been demonstrated to have antiepileptic activity. Recent studies have shown that SSa could inhibit NMDA receptor current and persistent sodium current. However, the effects of SSa on potassium (K(+)) currents

[Effect of saikosaponins on epileptic rat electroenciphalogram].

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OBJECTIVE To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies. METHODS Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3

[Effect of saikosaponin alpha on experimental epilepsy in rats].

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OBJECTIVE To investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats. METHODS Acute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the

Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway.

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OBJECTIVE Saikosaponin a (SSa), which is one major bioactive compound isolated from radix bupleuri, has been demonstrated to exhibit the properties of anticonvulsant and antiepileptic in few reports. This study aims to clarify the molecular mechanism by which SSa protects against pentylenetetrazol

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy.

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UNASSIGNED Chronic temporal lobe epilepsy (cTLE) is the most common intractable epilepsy. Recent studies have shown that saikosaponin A (SSa) could inhibit epileptiform discharges induced by 4 action potentials and selectively increase the transient inactivating K+ currents (IA). However, the

[Chemical constituents analysis on anticonvulsive effect of three extracts from radix bupleuri].

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OBJECTIVE To study the relationship between anticonvulsive effect of three extracts from Radix Bupleuri and their chemical compositions. METHODS Volatile oil component, saikosaponin component and water-soluble component were extracted with SFE-CO2 from Radix Bupleuri, their effect on MES and PTZ

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