schumanniophyton magnificum/alkaloid

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Novel Chromone Alkaloids from Schumanniophyton magnificum.

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Six chromone alkaloids were isolated from the root bark of SCHUMANNIOPHYTON MAGNIFICUM Harms. Three of these were identified as the known alkaloids schumanniophytine, schumannificine and N-methylschumannificine. The other three alkaloids are novel and were named isoschumanniophytine,

Further Chromone Alkaloids from Schumanniophyton magnificum.

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Six further alkaloids have been isolated from the water-soluble fraction of the ethanolic extract of SCHUMANNIOPHYTON MAGNIFICUM Harms. Two of these are the known compounds trigonelline and rohitukine but the other four compounds are novel. Two of these, named schumagnine and N-methylschumagnine,

Novel Structures of two Chromone Alkaloids from Root-Bark of Schumanniophyton magnificum.

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The constitutional formulae of two new chromone alkaloids, schumannificine 2 and N-methylschumannificine 3 isolated from the root-bark of SCHUMANNIOPHYTON MAGNIFICUM, H ARMS, have been shown to be linear tetracyclic compounds with ring D being piperidine in nature, on the basis of the chemical

New Chromone Alkaloids from the Stem Bark of Schumanniophyton magnificum.

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Fractionation of a methanolic extract of the stem bark of SCHUMANNIOPHYTON MAGNIFICUM yielded large quantities of mannitol. In addition, noreugenin and ten related chromone alkaloids were isolated. Seven of these alkaloids had been isolated previously from S. MAGNIFICUM and one other from

Heteronuclear NMR studies of the chromone alkaloids and revision of the structure of some piperidino-chromone alkaloids.

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The 13C-NMR spectra of seven chromone alkaloids isolated from Schumanniophyton magnificum have been obtained. Assignment of signals was carried out with the help of heteronuclear coupling experiments and other correlation techniques on the alkaloids and their acyl derivatives. On the basis of the

Fusarium proliferatum, an endophytic fungus from Dysoxylum binectariferum Hook.f, produces rohitukine, a chromane alkaloid possessing anti-cancer activity.

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Rohitukine is a chromane alkaloid possessing anti-inflammatory, anti-cancer and immuno-modulatory properties. The compound was first reported from Amoora rohituka (Meliaceae) and later from Dysoxylum binectariferum (Meliaceae) and Schumanniophyton problematicum (Rubiaceae). Flavopiridol, a

Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb).Wight & Arn.

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Rohitukine, a chromone alkaloid, has gained considerable international attention in recent years because of its novel semi-synthetic derivative, flavopiridol and P-276-00. Both these molecules are in advanced stages of clinical development and trial for cancer treatment. Recently, flavopiridol was

Antiviral activity of natural and semi-synthetic chromone alkaloids.

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The activity against human immunodeficiency virus (HIV) and herpes simplex virus (HSV), of the non-polar fraction of a methanolic extract of the rootbark of Schumanniophyton magnificum was found to be present in a fraction containing the chromone secondary amine schumannificine 1. Other chromone

Revision of Structures of some Schumanniophyton Alkaloids.

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The structures of isoschumanniophytine and N-methylschumannificine have been revised on the basis of NOE experiments and their reaction with Gibb's reagent. Revised structures are also proposed for schumannificine, anhydroschumannificine and N-methylanhydroschumannificine.

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