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Taxus - the panacea for cancer treatment.

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Cancer has been major challenge for healthcare sector for a long time. The use of chemotherapy and radiation therapy has its obvious side effects. The scientists have been looking to natural remedies for the treatment of cancer. There have been significant discoveries in this direction such as

Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei).

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Taxol is currently a valuable anticancer drug; however, the accumulated mixture of taxoids can vary greatly among Taxus species. So far, there is very little genomic information for the genus Taxus, except for Taxus baccata. Transcriptome analysis is a powerful approach to explore the different

Comparative proteomic analyses of two Taxus species (Taxus × media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites.

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Taxus species are well-known for paclitaxel, which exhibits antitumor activities and is used for treating various cancers. Although most Taxus species are widespread in many areas, few studies have characterized the variation in metabolism among different Taxus species. Using an integrated approach

Two new antineoplastic diterpenes from Taxus mairei.

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Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.

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New sources for the antitumor natural product taxol [1] are needed as demands for this promising cancer chemotherapeutic agent increase. Presently, supplies of taxol for clinical studies are obtained from the bark of Taxus brevifolia, a potentially limited source. Using analytical methods, the

The Research Progress of taxol in Taxus

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Background: Taxus is a valuable woody species with important medicinal value. The bark of Taxus can produce taxol, a natural antineoplastic drug that is widely used in the treatment of breast, ovarian and lung cancers. However, the low

Taxol content of various Taxus species in Hungary.

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The anticancer drug taxol was separated and quantitatively determined in bark and foliage of different Taxus species by high-performance liquid chromatography to prove the presence of taxol in Hungarian Taxus species. The measurements were carried out with photodiode array detection using a porous

[On the conservation and regeneration of Taxus resources].

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In recent years, the taxol isolated from the stem bark of some plants of Taxus has been widely as an antitumor agent. But the development of taxol is limited by the scarcity of wild Taxus resources. This paper seeks to discuss the ways to conserve and promote the regeneration of these resources.

Ethnomedical properties of taxus wallichiana zucc. (Himalayan yew).

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Taxus wallichiana Zucc., known as Himalayan yew, belongs to the family Taxaceae. It is a medium-sized, temperate, Himalayan forest tree of medicinal importance. In India, this evergreen tree is found at altitudes between 1800 and 3300 m above mean sea level (MSL). It has been used by the native

Antitumor effect of water decoctions of taxus cuspidate on pancreatic cancer.

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The Taxus cuspidate has been used as a traditional Chinese medicinal herb and considered to affect various physiological functions in the body for thousands of years. As we know that taxol isolated from the Taxus cuspidate has been approved for the treatment of ovarian cancer, it has also shown its

[Studies on the chemical constituents of Taxus yunnanensis].

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The ethanolic extract of the bark of Taxus yunnanensis Cheng et L. K. Fu. showed significant antineoplastic effect on the transplantable tumors in mice. The life survival of P388 leukemic bearing mice was increased (84%) and the growth of B16 melanoma in mice was inhibited (53%). From this extract

Cell lines of Taxus species as source of the anticancer drug taxol.

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Callus culture of Taxus baccata and Taxus x Media were induced using explants of young stems and female gametophyte. Culture conditions have been established for the cell suspension of the different callus cell lines. Callus were induced from Taxus baccata and Taxus x Media using Murashige and Skoog

Molecular, structural, and phylogenetic analyses of Taxus chinensis JAZs.

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Taxus spp. are ancient gymnosperms that produce a unique secondary metabolite, namely, taxol, an anticancer drug. JAZ proteins are key regulators of the JA signaling pathway, which control taxol biosynthesis. However, the JAZ proteins of Taxus spp. are poorly studied. In this work, nine JAZ genes

Taxanes in Taxus baccata pollen: cardiotoxicity and/or allergenicity?

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Diterpenic alkaloids belonging to taxine (yield: 0.18 % dry weight) and taxoids (paclitaxel, baccatine III and 10-deacetylbaccatine III, cumulated yield: 0.004 % dry weight) were isolated from Taxus baccata L. pollen. Moreover, taxoids conjugated to macromolecules were also detected by ELISA.

Taxus canadensis abundant taxane: conversion to paclitaxel and rearrangements.

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An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes

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