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Increases in skin resistance of white rats following scopolamine injection.

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Thirty-six male albino rats were injected with either saline or 0.6 mg/kg scopolamine and placed on a metal grid. The grid was wired to a transistor-biased detector which determined, every second, whether the subject's resistance was above or below a preset threshold value. Over test sessions of

Relative effects of scopolamine and electroconvulsive shock upon habit reversal in white rats.

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30 adult male white rats were equally divided into control, scopolamine, and electroconvulsive shock groups to learn 20 successive reversal problems in an E-maze for water after 23 1/2 hr. of deprivation. The noncorrection method was used. After 1 mo. of preliminary training, each scopolamine animal

The effects of intrahippocampal scopolamine infusions on anxiety in rats as measured by the black-white box test.

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Hippocampal cholinergic projections mediate attention to arousing stimuli as demonstrated by behavioral, electrophysiological, and endocrine studies. We recently reported that peripheral injections of the cholinergic antagonist scopolamine (SCOP) increased anxiety-like behaviour (ALB) in rats and we

A pharmacologic investigation of the 'transport response' in the white rat.

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In a series of six experiments, the ability of specific neurotransmitter antagonists to alter the 'transport response' was investigated in 19-day-old rat pups. The serotonergic blocker, methysergide, and the cholinergic blocker, scopolamine, did not produce any consistent changes in the intensity of

Muscarinic antagonists are anxiogenic in rats tested in the black-white box.

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Central cholinergic (ACh) projections have been shown to modulate stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis and are integral to the expression of electrophysiological correlates of arousal, namely hippocampal theta rhythm. The degree to which these actions of ACh are

Positive identification of the principal component of a white powder as scopolamine by quantitative one-dimensional and two-dimensional NMR techniques.

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An unidentified white powder collected as evidence in an intelligence investigation was characterized exclusively by nuclear magnetic resonance (NMR) analysis. A small fraction of the powder dissolved in D2O was subjected to a series of one- and two-dimensional techniques which were used to

On the Straub-Herrmann mouse tail reaction on injection of alkaloids of opium and mixtures of these with scopolamine into white mice.

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Comparative study of korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function.

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This study evaluated cholineresterase inhibitory activity of Korean white ginseng extract (WGE), red ginseng extract (RGE), and black ginseng extract (BGE) and the cholinergic effect on scopolamine (SCOP)-induced amnesic mice. WGE, RGE, and BGE inhibited acetylcholineserase (AChE), as well as

[The participation of glutaminergic transmission in the mechanism of movement disorders induced by reverse rotation in white mice].

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Administration of MK-801 or IEM-1754 prevented akinesia in mice induced by reversing rotation, not less effectively than scopolamine. Quaternary adamantane derivative IEM-1857 was ineffective. IEM-1925 enhanced the locomotor disturbance induced by reversing rotation due, probably, to different

The involvement of glutamatergic transmission in the mechanism of movement disorders induced by reversive rotation of white mice.

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The ability of the selective non-competitive NMDA receptor blocker MK-801 and a series of new glutamate antagonists --the adamantane derivatives IEM-1754 and IEM-1857 and phencyclidine (IEM-1925)--to prevent movement disorders induced by reversive rotation in mice was studied. l.p. MK-801 at a dose

A reappraisal of scopolamine effects on inhibition.

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A series of related experiments was conducted to examine the effects of scopolamine on discrimination performance in the presence or absence of a stimulus signalling non-reinforcement. In Experiment 1, rats trained to respond on 1 of two levers in the presence of a 1000-Hz tone and on the other

Scopolamine impairs the response-to-change following observation of the environment but not after its exploration by the rat.

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The tendency to select the T-maze arm that has been changed in brightness between two successive trials (response-to-change) was investigated in rats injected with scopolamine (Sc) or saline (NaCl) 20 min before the test. In the "passive" version of the test, when in trial 1 rats could inspect the

Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging.

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Cognitive impairment resulting from disruption of cholinergic function may occur through modulation of cerebrovascular volume (CBV). In the present study, dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) was used to examine cerebrovascular volume in young and old dogs during

Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine.

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BACKGROUND Phosphatidylcholine (PC), the major source of dietary choline, has been demonstrated to improve the capability of learning and memory in rodent and the amelioration of long-chain n-3 polyunsaturated fatty acids (PUFA) on anti-aging and anti-oxidation is widely known as well. In this

Effects of intensity and type of prepulse stimulus on prepulse inhibition in scopolamine treated rats.

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Prepulse inhibition (PPI) of the auditory startle response (ASR) is a behavioral test that has been used to measure auditory thresholds, to assess sensory-motor integration functions, and its use has been recommended in the United States Environmental Protection Agency Developmental Neurotoxicity

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