Effect of Soft Fruit on Postprandial Blood Glucose
Ключевые слова
абстрактный
Описание
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
There will be a one week minimum wash out period between each intervention. All interventions will be randomised and blinded as far as possible in a cross-over design where the volunteers are acting as their own control. The volunteers will be asked to consume a low phytochemical diet three days prior to taking the currants all occasions. In addition, they will be asked to record what they ate over the same period in a simple food diary.
The following intervention will be carried out on 16 overweight/obese male/postmenopausal female non-smoker volunteers:
1. Control: sugar matched (matched to currant sugar content) water with polycal (complex carbohydrate load)
2. Blackcurrants (which contain anthocyanins; 200grams) with polycal (complex carbohydrate load)
3. Blackcurrants (which contain anthocyanins; 200grams) with glucose (simple carbohydrate load)
4. Greencurrants (which naturally contain no anthocyanins; 200grams) with polycal (complex carbohydrate load)
Note: the polycal will contain the equivalent glucose load as given in intervention 3 assuming complete hydrolysis of all carbohydrates.
Даты
| Последняя проверка: | 03/31/2019 |
| Первый отправленный: | 11/10/2014 |
| Предполагаемая регистрация отправлена: | 11/12/2014 |
| Первое сообщение: | 11/13/2014 |
| Последнее обновление отправлено: | 04/15/2019 |
| Последнее обновление опубликовано: | 04/16/2019 |
| Фактическая дата начала исследования: | 10/31/2014 |
| Предполагаемая дата завершения начальной школы: | 08/31/2019 |
| Предполагаемая дата завершения исследования: | 08/31/2019 |
Состояние или болезнь
Вмешательство / лечение
Dietary Supplement: Blackcurrants with polycal OGTT
Dietary Supplement: Greencurrants with polycal OGTT
Dietary Supplement: Blackcurrants with glucose OGTT
Dietary Supplement: Sugar matched water with polycal OGTT
Фаза
Группы рук
| Рука | Вмешательство / лечение |
|---|---|
| Experimental: Sugar matched water with polycal OGTT Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Sugar matched water with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Blackcurrants with polycal OGTT Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants ( 200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Blackcurrants with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Blackcurrants with glucose OGTT Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments | Dietary Supplement: Blackcurrants with glucose OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
| Experimental: Greencurrants with polycal OGTT Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments. | Dietary Supplement: Greencurrants with polycal OGTT Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups |
Критерии приемлемости
| Возраст, имеющий право на обучение | 21 Years Чтобы 21 Years |
| Полы, имеющие право на обучение | All |
| Принимает здоровых добровольцев | да |
| Критерии | Inclusion Criteria: - Obese male or female (postmenopausal) healthy non-smoking volunteers (BMI over 25kg/m2) - Aged >21 and <70 years Exclusion Criteria: - Medical exclusion criteria - Chronic illness, including: - thromboembolic or coagulation disease - unregulated thyroid disease - kidney disease - hepatic disease - severe gastrointestinal disorders - pulmonary disease (e.g. chronic bronchitis, COPD) - diabetes - Alcohol or any other substance abuse - Eating disorders - Psychiatric disorders (including severe depression, lithium treatment, schizophrenia, severe behavioural disorders) - Non-postmenopausal women - Medication exclusion criteria - Oral steroids - Tricyclic antidepressants, neuroleptics - Anticoagulants - Digoxin and anti-arrhythmics - Chronic use of anti-inflammatories (e.g. high doses of aspirin, ibuprofen), Insulin, -Sulphonylureas, Thiazolidinediones (glitazones), metformin. - Anti-obesity medication e.g. Orlistat |
Результат
Основные показатели результатов
1. Plasma Glucose Area Under the Curve [Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion]
Меры вторичного результата
1. Plasma Insulin Area Under the Curve [Plasma was collected at -15, -10 and -5 (fasted) and at 15, 30, 45, 60, 90, 120, 150 and 300 min post currant ingestion]
