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Acute Mesenteric Venous Thrombosis.. in Assiut University Hospital Management Controversies

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Assiut University

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Initial treatment in the management of acute mesenteric vein thrombosis (MVT) is controversial. Some authors have proposed a surgical approach, whereas others have advocated medical therapy (anticoagulation). In this study, the investigators analyzed and compared the results obtained with surgical and medical treatment to determine the best initial management for this disease.

Описание

Mesenteric venous thrombosis (MVT) is increasingly recognized as a cause of mesenteric ischemia. it must be distinguished from arterial and non occlusive types of ischemia, it accounts for 5% to 15% of all cases of mesenteric ischemia. Patients may have evocative signs,such as abdominal pain that is out of proportion to physical signs, nausea, or vomiting. However, a clinical diagnosis is often difficult because abdominal symptoms are non specific and high index of suspicion is often required for diagnosis.(1) Primary MVT accounted for 25% to 55% of cases in early studies, but recent reports show decline in primary MVT because of improvements in the diagnosis of hypercoagulable states.(2) Advances in new imaging techniques also have enabled early recognition of this disease without or before laparotomy.(3-5 ) Fortunately , there is no consensus about the initial management of MVT; Some authors have proposed an aggressive surgical approach (6) while others have advocated an initial conservative management with anticoagulation and close monitoring . ( 7) similarly,issue of second look laparotomy,mandatory or selective is yet not resolved.

The present study is prompted to analyze our experience in an effort to resolve these controversies and the results obtained will be assessed to determine the best management strategy for this uncommon disease.

Даты

Последняя проверка: 12/31/2017
Первый отправленный: 01/19/2018
Предполагаемая регистрация отправлена: 03/28/2018
Первое сообщение: 03/29/2018
Последнее обновление отправлено: 03/28/2018
Последнее обновление опубликовано: 03/29/2018
Фактическая дата начала исследования: 03/31/2018
Предполагаемая дата завершения начальной школы: 11/30/2019
Предполагаемая дата завершения исследования: 11/30/2019

Состояние или болезнь

Mesenteric Vein Thrombosis

Вмешательство / лечение

Drug: Warfarin

Procedure: MVT with failure of anticoagulation therapy

Drug: Heparin

Фаза

-

Группы рук

РукаВмешательство / лечение
Experimental: MVT with anticoagulation therapy(heparin &warfarin)
patients with confirmed diagnosis of acute MVT on CT scan but having no signs of peritonitis or established CT signs of gangrene will be treated conservatively with anticoagulation(heparin &warfarin) while other cases will be for surgical management and not included in the study.
Experimental: MVT with failure of anticoagulation therapy(heparin &warfarin)
patients who underwent conservative therapy with anticoagulation (heparin &warfarin) but showed no improvement .

Критерии приемлемости

Возраст, имеющий право на обучение 18 Years Чтобы 18 Years
Полы, имеющие право на обучениеAll
Принимает здоровых добровольцевда
Критерии

Inclusion Criteria:

- 1. Patients admitted in the department of surgery in Assiut University diagnosed to have mesenteric venous occlusion not presented by signs of peritonitis or confirmed radiological signs of bowel infarction.

Exclusion Criteria:

1-Patients diagnosed to have mesenteric venous occlusion but with signs of peritonitis or confirmed radiological signs of bowel infarction on admission.

Результат

Основные показатели результатов

1. Anticoagulation therapy (heparin &warfarin) in MVO [within 3-6 months of starting treatment.]

patients with confirmed diagnosis of acute MVT on CT scan will be treated conservatively In addition to usual care such as fluid and electrolyte balance, antibiotic coverage and nasogastric intubation ,intravenous heparin will be started and the dose is adjusted to maintain APTT levels at 2-2.5 times the normal. followed by oral anticoagulation (warfarin) for 6 months or for life in the presence of coagulation abnormality. All patients will be critically followed up(Clinically.. Radiologically ) for the progress of response of therapy , failure to improve or worsening in condition( appearance of signs of peritonitis such as guarding, rigidity and fever...or radiological signs of bowel infarction) will be assessed . Factors that may affect the response such as ( age, duration from onset of the disease till starting therapy,underlying diseases,.. )also complications (hemorrhage, failure ,..)will be assessed

Меры вторичного результата

1. Recurrence rate [within six months of starting treatment.]

number of recurrent cases post conservative therapy .

2. Mortality rate [within one year of starting treatment.]

number of deaths as a complication of conservative therapy or surgery

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