Microneedle and Trichloroaceticacid in Treatment of Melasma
Ключевые слова
абстрактный
Описание
As regards management, the therapeutic options range from photoprotection, topical hypopigmenting agents, chemical peels and lasers. There are variety of less-tried systemic agents like fish oil, green tea and . Although no single agent has proved to be effective for all patients, a combination of two or three agents is often tried to achieve optimum results.
Chemical peeling is the application of a chemical agent to the skin, which causes the controlled destruction of a part or of the entire epidermis, with or without the dermis, leading to exfoliation and removal of superficial lesions, followed by the regeneration of new epidermal and dermal tissues.
Chemical peels are a well-known modality of treatment for melasma. The basic mechanism of the action of chemical peels in melasma is the removal of unwanted melanin by causing a controlled chemical burn to the skin.
Trichlroacetic acid peeling has been the gold standard in chemical peeling for many decades.
For superficial peels Trichlroacetic acid 10% to 25% are used. some authors consider up to 35% Trichlroacetic acid as also a superficial.
Skin microneedling is a technique predominantly used to improve the appearance of cutaneous scarring and photo damage.
Fine needles puncture the skin, resulting in increased dermal elastin and collagen, collagen remodelling, and thickening of the epidermis and dermis. Additionally, skin needling creates small channels, which increase the absorption of topically applied preparations A property which has been used in various dermatological treatments.
Даты
| Последняя проверка: | 01/31/2018 |
| Первый отправленный: | 02/06/2018 |
| Предполагаемая регистрация отправлена: | 03/19/2018 |
| Первое сообщение: | 03/20/2018 |
| Последнее обновление отправлено: | 03/19/2018 |
| Последнее обновление опубликовано: | 03/20/2018 |
| Фактическая дата начала исследования: | 04/04/2018 |
| Предполагаемая дата завершения начальной школы: | 04/04/2019 |
| Предполагаемая дата завершения исследования: | 04/04/2020 |
Состояние или болезнь
Вмешательство / лечение
Device: Microneedle
Фаза
Группы рук
| Рука | Вмешательство / лечение |
|---|---|
| Active Comparator: A include 20 patients will be treated with TCA25% +microneedle 8 sessions for TCA 25 peel and 4 sessions for microneedle (derma pen). | |
| Active Comparator: B include 20 patient will be treated with TCA 25% only ( 8 sessions) |
Критерии приемлемости
| Возраст, имеющий право на обучение | 18 Years Чтобы 18 Years |
| Полы, имеющие право на обучение | All |
| Принимает здоровых добровольцев | да |
| Критерии | Inclusion Criteria: - Both sex will be included Age range from 18- 50 yrs.' old Patients with realistic expectations. Exclusion Criteria: - patients taking oral contraceptive pills. patients with history of polycystic ovary. pregnant and lactating females. patients with active infection. patients on isotretinoin. patients with history of keloids,or hypertrophic scars. |
Результат
Основные показатели результатов
1. Scoring of the patients according to modified melasma are abd severity index [mMASI] Scoring before and After last session will be done by 1 month [1 month after last session]
2. [mMASI] Scoring before and After last session will be done by 3 months [3 months after last session]
