Posterior Capsule Opacification After Lens Capsule Polishing
Ключевые слова
абстрактный
Описание
Cataract, the clouding if the eye's lens, is the leading cause of blindness worldwide, with phacoemulsification and implantation of an intraocular lens being the only therapeutic option. Cataract surgery is nowadays considered a safe and efficient procedure. However, one of the most frequent complications after surgery is posterior capsule opacification (PCO), that results in diminished postoperative visual acuity. PCO occurs due to remaining lens epithelial cells in the capsular bag, that start to migrate and proliferate.
PCO can be easily treated by performing a neodymium-doped yttrium aluminium garnet (Nd-YAG) laser capsulotomy. However, even if laser capsulotomy is considered a simple procedure, possible complications are rise of intraocular pressure, inflammation, cystoid macular edema, or retinal detachment. Furthermore, several patients are no suitable candidates for laser capsulotomy, for example children and patients with high myopia.
Therefore, it would be necessery to identify different approaches to prevent generation of PCO. One approach could be "cleaning" of the lens epithelial cells in the capsular bag by polishing of the lens capsule during surgery. Hence, the aim of this study is to examine whether capsular polishing is beneficial to decrease the growth and proliferation of LECs.
Даты
| Последняя проверка: | 02/29/2020 |
| Первый отправленный: | 02/25/2019 |
| Предполагаемая регистрация отправлена: | 02/26/2019 |
| Первое сообщение: | 02/27/2019 |
| Последнее обновление отправлено: | 03/12/2020 |
| Последнее обновление опубликовано: | 03/15/2020 |
| Фактическая дата начала исследования: | 02/12/2019 |
| Предполагаемая дата завершения начальной школы: | 04/30/2020 |
| Предполагаемая дата завершения исследования: | 01/31/2021 |
Состояние или болезнь
Вмешательство / лечение
Procedure: Capsular polishing
Other: Non capsular polishing
Фаза
Группы рук
| Рука | Вмешательство / лечение |
|---|---|
| Sham Comparator: Non capsular polishing No capsular polishing taking place during cataract surgery | Other: Non capsular polishing No capsular polishing taking place during cataract surgery |
| Active Comparator: Capsular polishing Capsular polishing taking place during cataract surgery | Procedure: Capsular polishing Capsular polishing taking place during cataract surgery |
Критерии приемлемости
| Возраст, имеющий право на обучение | 21 Years Чтобы 21 Years |
| Полы, имеющие право на обучение | All |
| Принимает здоровых добровольцев | да |
| Критерии | Inclusion Criteria: - Age-related cataract. - Patients in the age group of 21 years and above. - Patients with uncomplicated cataract. - Patients without any relevant systemic or ocular morbidity. - Patients with well dilating pupils. - Written informed consent prior to any study specific action. Exclusion Criteria: - Patients with complicated cataract. - Patients having corneal pathology. - Patients with any form of ocular inflammation. - Patients with glaucoma, retinal pathologies. - Patients with traumatic cataracts, subluxated and dislocated lens, prior h/o ocular surgery, pseudoexfoliation. - Any intraoperative complications like posterior capsule rupture. - In case of pregnancy (pregnancy test will be taken preoperatively in women of reproductive age) |
Результат
Основные показатели результатов
1. Comparison between eye with capsular polishing and eye without capsular polishing concerning generation of posterior capsule opacification (PCO) in the same patient [6 months]
Меры вторичного результата
1. Difference in the number of cells in the anterior chamber between the eye with capsular polishing and the eye without capsular polishing in the same patient [6 months]
