Salt Sensitivity Hypertension and Lens Opacities
Ключевые слова
абстрактный
Описание
The number of patients with hypertension (HT) worldwide is estimated to reach 1.56 billion by 2025.HT accounts for almost 50% of deaths due to stroke and coronary artery disease. Salt-sensitive hypertension (SSH) accounts for about the half of all HT cases. Na+ /K+-ATPase activity is impaired in patients with SSH . Impaired Na+ /K+-ATPase activity in the lens epithelium results in cortical opacities in the peripheral equatorial region of the lens.A definite diagnosis of salt sensitivity is difficult, expensive, and associated with low patient compliance. Salt sensitivity is a risk factor for cardiovascular mortality and morbidity regardless of blood pressure and for other diseases such as asthma, gastric carcinoma, osteoporosis, and renal dysfunction. The present study is the first to investigate the potential of using lens opacity to predict SSH.
The transparency of the whole lens is largely based on epithelial cell permeability and Na+ /K+-ATPase activity. Circulation is activated by Na+ /K+-ATPases, which are present at 20-fold normal concentrations, particularly in the equatorial than in the anterior epithelial cells.
The mechanisms associated with SSH pathogenesis, such as signaling pathways involving Src family kinase (SFK), endothelin, connexin, brain natriuretic peptide (BNP), aldosterone, transient receptor protein V4 (TRPV4) ion channel, with-no-lysine kinase-Ste20-like proline/alanine rich kinase/oxidative stress-responsive kinase 1 (WNK-SPAK/OSR1), and Ras-related C3 botulinum toxin substrate (Rac1) , are important to the physiology of the lens epithelium. Compelling studies suggest that inhibition of these pathways may facilitate opacity.
Даты
Последняя проверка: | 11/30/2017 |
Первый отправленный: | 12/19/2017 |
Предполагаемая регистрация отправлена: | 12/25/2017 |
Первое сообщение: | 12/27/2017 |
Последнее обновление отправлено: | 12/26/2017 |
Последнее обновление опубликовано: | 12/28/2017 |
Фактическая дата начала исследования: | 03/14/2017 |
Предполагаемая дата завершения начальной школы: | 12/06/2017 |
Предполагаемая дата завершения исследования: | 12/06/2017 |
Состояние или болезнь
Вмешательство / лечение
Diagnostic Test: Lens examination
Фаза
Группы рук
Рука | Вмешательство / лечение |
---|---|
Salt-sensitive group Patients (n:163)with HT who presented at the emergency service at least once with a minimum increase in their systolic and diastolic blood pressure of 10% after consuming salty foods were included in the SSH group.
Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements | |
Salt resistance group Patients(n:142) who did not exhibit this increase were included in the SRH group
Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements | |
Control group Sex- and age-matched patients(n:124) without a HT diagnosis were included in the control group.
Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements |
Критерии приемлемости
Возраст, имеющий право на обучение | 40 Years Чтобы 40 Years |
Полы, имеющие право на обучение | All |
Метод отбора проб | Probability Sample |
Принимает здоровых добровольцев | да |
Критерии | Inclusion Criteria: Salt Sensitivity Hypertension patients Non-SSH, salt-resistant HT (SRH) patients Control patients without HT, aged 40-80 years. Exclusion Criteria: Cataracts Diabetes Mellitus Smoking Hypo/hypercalcemia Hyperparathyroidism Eye trauma Coronary artery disease Cardiac failure Renal failure - |
Результат
Основные показатели результатов
1. Lens examination [6 months]