Weight Loss Impact on Male Fertility
Ключевые слова
абстрактный
Даты
| Последняя проверка: | 11/30/2019 |
| Первый отправленный: | 04/20/2019 |
| Предполагаемая регистрация отправлена: | 12/01/2019 |
| Первое сообщение: | 12/04/2019 |
| Последнее обновление отправлено: | 12/01/2019 |
| Последнее обновление опубликовано: | 12/04/2019 |
| Фактическая дата начала исследования: | 01/09/2019 |
| Предполагаемая дата завершения начальной школы: | 12/31/2019 |
| Предполагаемая дата завершения исследования: | 12/31/2019 |
Состояние или болезнь
Вмешательство / лечение
Dietary Supplement: Weight loss
Фаза
Группы рук
| Рука | Вмешательство / лечение |
|---|---|
| Experimental: Weight loss | Dietary Supplement: Weight loss Patients will be submitted to very low-calorie ketogenic dietary intervention (VLCK) according to the recommendations of the Pronokal® Method program including lifestyle and physical activity guidelines. The ketogenic stage (phase 1-3) consists of a VLCD diet (600-800 kcal / d), with low carbohydrate intake and lipids. The amount of high biological value proteins ranges from 0.8 to 1.2 g / kg of body weight / day. This first stage (ketogenic) is maintained until the patient reaches the goal of reducing the target weight by 80% to be reduced, being variable in time, according to the response of each patient. After this period, it evolved to a non-ketogenic stage, initiating the hypocaloric diet (800 to 1500 Kcal), with progressive introduction of other food groups, reducing weight more slowly. The maintenance stage consists of a balanced diet, ranging from 1500 to 2000 Kcal. |
Критерии приемлемости
| Возраст, имеющий право на обучение | 18 Years Чтобы 18 Years |
| Полы, имеющие право на обучение | Male |
| Принимает здоровых добровольцев | да |
| Критерии | Inclusion Criteria: Obesity in male patients - Metabolic Syndrome (NCEP-ATP III) - Alteration of some of the seminal parameters evaluated in conventional seminal analysis Exclusion Criteria: - Other causes of hypogonadotrophic hypogonadism - Hypergonadotrophic hypogonadism - Contraindications for performance of ketogenic diet: - Type 1 or type 2 diabetes mellitus in insulin use - Food drive - Alcoholism or drug addiction - Severe psychiatric illness - Use of coumarin anticoagulants - Hepatic insufficiency - Severe renal impairment - Hematologic diseases - Cancer in activity, - Cardiovascular or cerebrovascular diseases (arrhythmias, recent myocardial infarction, unstable angina, decompensated heart failure, recent stroke) - Gout - Renal or biliary lithiasis - Major depression or other serious psychiatric illness. |
Результат
Основные показатели результатов
1. Seminal evaluation [Six months]
2. Seminal evaluation [Six months]
3. Seminal evaluation [Six months]
Меры вторичного результата
1. Metabolic response [Six months]
2. Hormonal measurements [Six months]
3. Inflamatory response [Six months]
4. Adipose tissue evaluation [Six months]
5. Microbiota evaluation [Six months]
6. Epigenetic evaluation [Six months]
7. Body composition changes [Six months]
8. Brow tissue study [Six months]
9. Adipose tissue toxins study [Six months]
