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anticholinergic/кариес зубов

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Anticholinergics and cavities.

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Long-term scopolamine treatment and dental caries.

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OBJECTIVE To investigate whether scopolamine, an anticholinergic agent which induces hyposalivation, represents a risk factor for the occurrence of dental caries. METHODS A retrospective cohort study was carried out among sailors treated with scopolamine for seasickness. The study population

Effects of treatments for drooling on caries risk in children and adolescents with cerebral palsy.

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Neuromuscular impairment makes individuals with cerebral palsy (CP) more prone to drooling. Among the treatment options, there are procedures that interfere with saliva production. It is imperative to evaluate the effect of the different modalities since the reduction in salivary flow

Rampant dental caries in the treatment of depression.

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Dental Caries are an uncommon, but significant side effect of the tricyclic antidepressants and other anticholinergic psychoactive drugs. The authors trace the etiological aspects of this syndrome including the effects of depression and antidepressant medication on salivary properties. A typical

Caries prevalence and associations with medications and medical comorbidities.

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OBJECTIVE To use extensive electronic dental, medical, and pharmacy databases to estimate the prevalence of dental caries in a cohort of new patients during a 5-year period (FY2010-FY2015) and determine whether medication use and medical comorbidities are associated with caries

The relationship between body mass index, the use of second-generation antipsychotics, and dental caries among hospitalized patients with schizophrenia.

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OBJECTIVE Weight gain is common in schizophrenia due to use of the second-generation antipsychotic medicines (SGAs). Studies have also shown that body mass index (BMI) and the side effect of SGAs, such as anticholinergic activity, are related to the risk of dental caries. This study aims to

Caries incidence and increments in community-living older adults with and without dementia.

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OBJECTIVE The Oral Health of Older Adults with Dementia was instigated in the late 1990s to quantify and compare coronal and root caries incidence and increments in community-living older Australians with and without dementia. METHODS A longitudinal design was used to conduct dental inspections at

The effect of chronic atropine treatment on salivary composition and caries in rats.

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Many instances of salivary dysfunction in humans can be traced to the use of medications that have hyposalivary side-effects. In this study, atropine, a cholinergic antagonist, was administered chronically to rats by use of osmotic mini-pumps. Steady-state blood levels, similar to levels obtained in

The problems of anticholinergic adverse effects in older patients.

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The old saying 'red as a beet, dry as a bone, blind as a bat, hot as a hare, mad as a hatter' is often quoted when describing the autonomic effects of drugs that block the muscarinic cholinergic system. These effects may be subtle or dramatic, yet can be overlooked or discounted as a natural

Use of psychotropic drugs and associated dental diseases.

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Patients with problems related to central nervous system dysfunctions are often treated with psychotropic drugs. These include antipsychotics, antidepressants, mood stabilizers, anticonvulsants, and drugs blocking specific receptors in the brain such as anticholinergics or beta-blockers. However,

Antiallergic effects of H1-receptor antagonists.

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The primary mechanism of antihistamine action in the treatment of allergic diseases is believed to be competitive antagonism of histamine binding to cellular receptors (specifically, the H1-receptors), which are present on nerve endings, smooth muscles, and glandular cells. This notion is supported

Alteration of the rat exocrine pancreas after chronic scopolamine administration.

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N-Methyl scopolamine (NMS) 25 mg kg-1 was given to rats for 14 days as a single daily intraperitoneal injection or by constant infusion through osmotic minipumps placed in the abdominal cavity. The anticholinergic drug reduced significantly body and pancreatic weights, and total pancreatic DNA

Oro-facial dyskinesia and the sub-commissural part of the globus pallidus in the cat: role of acetylcholine and its interaction with GABA.

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The possible role of cholinergic mechanisms in the sub-commissural part of the globus pallidus (scGP) in the induction of oro-facial dyskinesia (OFD) was studied in cats. Local injections of the cholinergic agonist carbachol into the scGP elicited tongue protrusions in a dose dependent way (100-1000

Trigger activation of the paradoxical salivatory response to atropine in the parasympathetically denervated human parotid gland.

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The author describes a specific intermediate condition of the response to atropine during the 2nd stage of denervation of the human parotid gland. Of the entire cohort of 110 subjects, some 20 subjects have been observed systematically. They demonstrated an extremely intense atropine salivation that

Design and development of a novel supportive care product for the treatment of sialorrhea in Parkinson's disease.

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Sialorrhea or excessive drooling is a significant medical issue in Parkinson's disease (PD) and neurodegenerative disorders, although it is often underreported by patients. Sialorrhea affects a large proportion of PD patients, ranging up to 78% in advanced stages, with many PD patients considering
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