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[Ketone body metabolism in children. 3. Plasma ketone body concentration in toxic form of infantile diarrhea].

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Metabolomics analysis revealed metabolic changes in patients with diarrhea-predominant irritable bowel syndrome and metabolic responses to a synbiotic yogurt intervention.

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OBJECTIVE Irritable bowel syndrome is a gastrointestinal disorder which can influence human metabolism. It has been demonstrated that probiotics are beneficial in controlling IBS. Thus, the main objective of the present study was to determine metabolic changes in response to diarrhea predominant

Mitochondrial DNA rearrangements with onset as chronic diarrhea with villous atrophy.

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We report two unrelated children with onset of chronic diarrhea and villous atrophy in the first years of life. Elevated plasma lactate concentrations and lactate/pyruvate and ketone body molar ratios suggested a genetic defect of oxidative phosphorylation. Analysis of the mitochondrial respiratory

Toxicology and carcinogenesis studies of methyl trans-styryl ketone (CAS NO 1896-62-4) in F344/N rats and B6C3F1 mice (feed and dermal studies).

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Methyl trans-styryl ketone is used as a synthetic flavoring agent and a fragrance additive in food and personal care products. Methyl trans-styryl ketone was nominated for study by the National Cancer Institute due to widespread human exposure as a flavoring and fragrance additive, positive results

Toxicologic studies on a novel antineoplastic bis-Mannich base, derived from a conjugated styryl ketone.

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A new bis-Mannich base (NC758) derived from a conjugated styryl ketone has demonstrated activities against human and animal tumors, both in vitro and as xenografts in athymic mice. The present study examined the toxicity of this candidate anticancer drug, when administered intraperitoneally by

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.

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Metabolomics studies have the potential to discover biomarkers. Fecal volatile organic compounds (VOCs) have been found to differ in patients with inflammatory bowel disease and irritable bowel syndrome. Murine models of colitis offer an alternative to human studies in which diet can be controlled.

[Clinical characteristics and long-term follow-up analysis of three cases with newborn aristolochic acid nephropathy].

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OBJECTIVE To summarize the clinical characteristics and prognosis of newborn aristolochic acid nephropathy induced by akebia. METHODS Retrospective analysis of clinical manifestations, therapy and prognosis was made upon data of 3 newborn infants with renal function lesion induced by

[Genetic diagnosis of fructose-1, 6-bisphosphatase deficiency: a case report].

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OBJECTIVE To report the first case of fructose-1,6-bisphosphatase (FBPase) deficiency diagnosed by genetic sequencing in China, and to improve the cognition of this rare disease. METHODS The clinical and laboratory characteristics of FBPase deficiency were reviewed, and the findings of direct

Acute pancreatitis with diabetic ketoacidosis associated with hypermyoglobinemia, acute renal failure, and DIC.

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We report a case of acute pancreatitis with diabetic ketoacidosis associated with increased serum myoglobin concentration, acute renal failure, and disseminated intravascular coagulation. A 49-year-old man suffering from diarrhea, vomiting, and somnolence was admitted to the hospital. He had had

Evaluation of 13-week repeated oral dose toxicity of Areca catechu in F344/N rats.

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This study investigated the potential toxicity of the Areca catechu water extract after 13-week repeated oral administration at 0, 166.7, 500, and 1500 mg/kg/day in rats. During the study period, clinical signs, mortality, body weight, food consumption, water consumption, urinalysis, estrous cycle,

Effectiveness of a nutraceutical supplement containing highly standardized perilla and ginger extracts in patients with functional dyspepsia.

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In Western countries functional dyspepsia (FD) has a prevalence of 10-20% among adults and although many drugs are currently available for use within clinical practice, FD remains an important challenge for physicians. Recently, food supplements that are ginger-based, along with other

[Ketoacidosis after cessation of chronic alcohol consumption].

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A 52-year-old man was admitted with diarrhea, near dehydration and dyspnoea. After many years of alcohol consumption, he had stopped drinking alcohol over a very short space of time and had eaten very little or nothing. He had tachypnoea, hypotension and an enlarged liver. Laboratory analysis

3-Hydroxy-3-methylglutaric aciduria with bilateral basal ganglia lesion: A case report.

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3-Hydroxy-3-methylglutaric aciduria (3-HMG, OMIN 246450) is a rare autosomal recessive metabolic disorder caused by a deficiency of 3-hydroxy-3-methylglutaryl-CoA lyase, a key enzyme in leucine metabolism and ketone body synthesis. Acute episodes of 3-HMG may be triggered by fasting or infection,

Utilization of different quantities of fat at high altitude.

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Investigations on utilization of fats have been carried out at altitudes of 3,500, 3,800, and 4,700 m, respectively, on 27, 7, and 12 soldiers staying at these altitudes for over 4 months in tentage accommodation. At 3,500 m the fat utilization was 95.9, 96.2, and 96.6% on intakes of 128, 168, and

Diabetic ketoacidosis associated with Guillain-Barré syndrome with autonomic dysfunction.

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A 37-year-old woman was admitted in a comatose state, after exhibiting fever and diarrhea. Diabetic ketoacidosis was diagnosed due to an increased blood glucose level (672 mg/dl), metabolic acidosis, and positive urinary ketone bodies. On the fifth hospital day, despite recovery from the critical

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