Patients in this arm will have conventional open lumbar discectomy operation.

Patients in this arm will have Percutaneous Endoscopic Translaminar lumbar discectomy operation using Easy Go system Endoscopy

Lumbar Disc Herniation

Removal of single level lumbar disc herniation through conventional discectomy.

Conventional open lumbar discectomy

Removal of single level Lumbar disc herniation using endoscope.

Percutaneous Endoscopic Translaminar lumbar discectomy.

This system will be used to remove herniated disc in endoscopic group

Easy Go system Endoscopy

Comparison Between Conventional vs. Endoscopic Lumbar Discectomy

Management of Lumbar Postero-lateral Single Level Disc Herniation: Comparative Study Between Conventional and Endoscopic Lumbar Discectomy

Improvement of preoperative low back pain and radicular pain.Clinical outcomes will be measured using Visual Analogue Scale.

Functional Improvement using modified MacNab's criteria

Such as neurological deficit, Cerebro-Spinal fluid (CSF) leak, wound infection...etc.

Demonstration of any disc herniation recurrence.

Length of incision needed by surgeon to complete each approach

H A Othman

Resident Doctor, Neurosurgery Department, Assiut Universiy Hosipitals

Assiut University

Part A: RG7388 as a single agent; given at a starting dose of 100 mg each day for five days for the first cycle which will be 56 days.
Part B: combination of RG7388 and Pegasys if subject does not achieve at least a PR by the end of 3 cycles of single agent RG7388

Polycythemia Vera

Essential Thrombocythemia

RG7388 is supplied as film-coated tablets at dosage strengths of 50 mg, 200 mg, 300mg and 400 mg.

RG7388

PEGASYS is supplied as a clear, sterile solution for subcutaneous (SQ) injection available in prefilled syringes. weekly doses at 45ug subcutaneously

Pegasys

Georgetown University Medical Center

Icahn School of Medicine at Mount Sinai

Wake Forest University Baptist Medical Center

Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemia

Open Label Phase I Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemia (With Pilot Feasibility Study in Combination With Pegylated Interferon Alfa 2a for Patients Who do Not Respond to the Single Agent at Each Dose Level)

sciatica/кровотечение

Comparison Between Conventional vs. Endoscopic Lumbar Discectomy

Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thrombocythemia

Самая полная база данных о лекарственных травах, подтвержденная наукой