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Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures.

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Antiseizure effects of progesterone (P) and its metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha, 5alpha-THP) were investigated following continuous vs. discontinuous P exposure. In Experiments 1, 32 cycling Long-Evans rats were administered kainic acid (32 mg/kg SC), ictal behavior was examined,

Enhanced ovarian gonadotropin receptors in the testosterone-induced polycystic ovary in rats.

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To establish the role of hormone receptors in patients with polycystic ovary (PCO), PCO rats were prepared by treating with testosterone propionate (TP). Five-day old immature female rats were subcutaneously injected with 1.25 mg TP in sesame oil. They were then killed at the age of 12 weeks. The

Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures.

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Progesterone has antiseizure effects, which may be due to the actions of its 5alpha-reduced metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP). Whether metabolism of progesterone to 3alpha,5alpha-THP in the hippocampus is essential for its antiseizure effects was investigated. In

Estrogen-priming can enhance progesterone's anti-seizure effects in part by increasing hippocampal levels of allopregnanolone.

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Estrogen can be proconvulsant, while progesterone and its metabolite allopregnanolone typically have anti-seizure effects. We investigated whether estrogen-priming also has anti-seizure effects by altering progesterone's metabolism to allopregnanolone, or levels of brain-derived neurotrophic factor

Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 2.

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Acute intravenous administration of the phytoestrogen genistein (G) blocks the gonadotropin-releasing hormone-(GnRH)-induced rise of luteinizing hormone (LH) in ovariectomized rats. The present experiments were performed to determine whether subacute administration of G or the mycoestrogens

Gas chromatographic-ion mobility spectrometry combined with a multivariate analysis model exploring the characteristic changes of odor components during the processing of black sesame

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Black sesame (Sesamum indicum L.) is a Chinese dietary herb that has been widely used in the medical and healthcare fields in China. According to the theory of Traditional Chinese medicine processing, reasonable processing (steaming and drying many times) can increase the tonic effect and reduce the

Cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats.

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We tested whether cyclic estradiol treatment, like continuous estradiol treatment, is sufficient to normalize meal size and body weight in ovariectomized rats. In Experiment 1, adult Long-Evans rats were ovariectomized and subcutaneously injected with 0, 0.2, or 2.0 microg estradiol benzoate (EB) in

Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats.

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Binge eating is more common in females than in males. This study investigated the effects of ovarian hormones on binge-eating behavior in a diet-related rat model. Six groups of ovariectomized Sprague-Dawley rats were used (n=13/group). All rats had continuous access to chow and water throughout the

Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.

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Progestins can have antiseizure effects; however, the mechanisms and sites of action of these effects are not well-understood. Whether progesterone's actions at GABA(A) receptors in the hippocampus are important for its antiseizure effects was investigated. In Experiment 1, ovariectomized rats were

Ethno medical studies in kailasagirikona forest range of chittoor district, andhra pradesh.

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The present study reveals the Ethno Botanical studies on uses of medicinal plants in Kailasagiri forest range of Chittoor district, Andhra Pradesh. Role of these studies in rural and forest economies is immense. Tribal people of this area have authentic information on medicinal values of different

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