A20-50 (2 capsules). Each capsule contains:
Yerba Mate (Ilex paraguariensis), Guarana seed (Paullinia cupana), Magnesium Oxide , Caffeine , Damiana (Turnera microphylla), Green tea (Camellia sinensis), Ginger (Zingiber Officinale), Kola nut (Cola acuminate or nitida), Pyridoxine Hydrochloride, Tibetan Ginseng root (Rhodiola crenulata), Schisandra (Schisandra Chinensis), Jujube (Ziziphus Jujuba) , Cocoa nut (Theobroma cacao), Chinese Skullcap (Scutellaria Baicalensis), Black tea leaf (Thea sinensis), Rice flour (to fill)
Dose = 2 capsules have a total of 200 mg of caffeine

YGD blend (2 capsules). Each capsule contains:
Yerba Maté (leaf) , Guarana (seed) , Damiana (leaf) , Rice flour: to fill ,
The 2 capsules of the YGD blend contain about 40 mg xanthines (caffeine and caffeine-like stimulants).

Placebo (2 capsules). Each capsule contains:
Rice Flour

Obesity

3-arm crossover study for investigation of the effect of herbal supplements A20-50 compared to YGD blend and placebo on subjective appetite sensations, glucose, insulin, ghrelin, GLP-1, CCK and ad libitum energy intake

Appetite suppressant properties of YGD and A20-50

Department Of Human Nutrition, Faculty of Science, University of Copenhagen

Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone

Assessment of subjective appetite sensations (visual analogue scales (VAS)) at time 0 (baseline - prior to the test meal) and at time 30, 45, 60, 90, 120, 150, 180 and 240 minutes post intake.
Measured subjective appetite sensations of hunger, satiety, prospective consumption, fullness, composite appetite score.

Assessment of subjective appetite sensations (visual analogue scales (VAS)) at time 0 (baseline - prior to the test meal) and at time 30, 45, 60, 90, 120, 150, 180 and 240 minutes post intake.
Measured subjective sensory desires for something sweet, salty, rich in fat, or meat/fish

A venflon catheter was secured into the participants' antecubital vein, and a blood sample was taken (baseline). Immediately after the subjects were served the test compound (2 capsules). Blood samples were taken at 15 and 30 minutes after intake of the test compound (2 capsules). After 30 minutes post test compound consumption (time 0), the subjects were given a standard breakfast (2.0 MJ: bun with cheese, yoghurt, 200 ml orange juice). Additional blood samples were taken 15, 30, 45, 60, 90, 120, 150, 180 and 240 minutes post-meal

240 min after each test meal an ad libitum meal was served, and the total energy intake was recorded

After completion of the adlibitum meal the subjects will rate the organoleptic quality of the meal by visual analogue scales (VAS) in regard to appearance, smell, taste, after-taste, and general palatability.

After completion of the ad libitum meal the subjects will rate the subjective appetite sensations by visual analogue scales (VAS) in regard to sensation of hunger, satiety, prospective consumption, fullness, composite appetite score and sensory desires to eat something sweet, salty, rich in fat, or meat/fish.

body weight will be measured to the nearest 0.05 kg on a decimal scale.

heart rate were measured using an automatically inflating cuff.

blood pressure were measured using an automatically inflating cuff.

Body composition will be assessed by electric bioimpedance using an Animeter.

Arne Astrup

Professor, Dr Med

University of Copenhagen

25 % calorie restriction respect measured total energy expenditure, using a Mediterranean diet

Prescription of diet 25 % lower than actual total energy expenditure in overweight or moderately obese premenopausal women

energy restricted mediterranean-type diet

25 % calorie restriction respect total energy expenditure

25 % calorie restriction

Clinica Alemana de Santiago

Calorie Restriction Retards the Aging Process

Calorie Restriction Retards the Aging Process by Inducing Sirtuins and Uncoupling Protein 3, Thereby Reducing the Production of Reactive Oxygen Species.

The main outcome measure will be UCP3 mRNA expression in vastus lateralis, which will be measured before and after the 3 month intervention period. This enzyme is the last link in the chain of events that occur after calorie restriction. Millet et al reported a value for UCP3 mRNA of 15 ± 1.5 amol/ìg total RNA in 18 subjects. Expecting a 60% increase over baseline in the expression of the enzyme, 17 subjects per group are required to obtain results with an á of 0.05 and a power of 0.8. Considering attrition rates, we must study 24 subjects per group.

Active BAT and its activation with cold exposure in humans, was demonstrated measuring 18 fluorodeoxyglucose uptake using PET-CT and colocalized the areas of 18F-FDG uptake to the expression of UCP1 thus for practical purposes it is a non invasive and reliable method to detect the presence of the tissue and the activity of UPC1, whic is downregulated by energy restriction.

yerba/потеря веса

Appetite Suppression Effects of an Herbal Combination of Yerba maté, Guarana, Damiana (YGD), and 12 Other Herbal Components, Versus YGD Supplementation Alone

Calorie Restriction Retards the Aging Process

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