Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

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Postavenie

Sponzori

First Affiliated Hospital, Sun Yat-Sen University

KLINICKÁ ŠTÚDIA: NCT03597373

BioSeek: nct03597373

Kľúčové slová

Abstrakt

Myasthenia gravis (MG) is an autoimmune disease that is characterized by muscle weakness and fatigue. The role of the thymus in MG has been suggested by the evidence that 10% to 15% of patients present with a thymoma and at least 60% with thymus hyperplasia or dysplasia.Beneficial effects of thymectomy in patients with MG have been described in 40% to 90%.Few studies have looked at the incidence of reintubation (not just within 24 hours after extubation), the factors associated with reintubation, and patient outcome.

Premature extubation may lead to hypercarbia, hypoxemia, pulmonary hypertension, right heart failure, and myocardial ischemia. Additionally, it subjects the patient to the physical risks of reintubation, including esophageal intubation, laryngeal trauma, and pulmonary aspiration. The purpose of the present study was to determine the incidence of reintubation, the variables associated with reintubation, and patient outcome

Popis

Inclusion was based on the availability of all the following possible predictive pre-operative variables: age, gender, weight, height, body mass index, diabetes, creatinine, duration of MG, severity of MG (based on Osserman's classification), pathological type of MG, history of myasthenic crisis, dose of pyridostigmine, use of a steroid hormone, and use of an immunosuppressant.operative variables: postoperative pulmonary infection, total duration of hospital stay, duration of ICU stay, and duration of postoperative hospital stay. Variables were collected by research assistants and maintained in a computer database.

Termíny

Naposledy overené:	06/30/2018
Prvý príspevok:	07/12/2018
Odhadovaná registrácia bola odoslaná:	07/19/2018
Prvý príspevok:	07/23/2018
Posledná aktualizácia bola odoslaná:	07/19/2018
Posledná aktualizácia bola zverejnená:	07/23/2018
Aktuálny dátum začatia štúdie:	12/31/2016
Odhadovaný dátum dokončenia primárneho okruhu:	12/31/2018
Odhadovaný dátum dokončenia štúdie:	12/31/2018

Stav alebo choroba

Myasthenia Gravis

Intervencia / liečba

Other: reintubation

Fáza

Skupiny zbraní

Arm	Intervencia / liečba
reintubation Reestablish of invasive mechanical ventilation
not reintubation Favourable respiratory function

Kritériá oprávnenosti

Vek vhodný na štúdium	18 Years To 18 Years
Pohlavia vhodné na štúdium	All
Metóda vzorkovania	Probability Sample
Prijíma zdravých dobrovoľníkov	Áno
Kritériá	Inclusion Criteria: - younger than 75 years - absence of heart failure as the primary indication for mechanical ventilation •Acute Physiology and Chronic Health Evaluation (APACHE) II score less than 12 points on day of extubation - body mass index less than 30 Exclusion Criteria: •preoperative moderate-to-severe chronic obstructive pulmonary disease

Výsledok

Primárne výstupné opatrenia

1. Risk Factors for Reintubation [an average of 30 days]

the reintubation rate was analyzed with logistic regression

Variables Predicting Reintubation After Thymectomy in Patients With Myasthenia Gravis

Kľúčové slová

ťažká myasténia

únava organizmu

hypoxia

asthenia

hyperplasia

ischemia

muscle weakness

thymoma

srdcové zlyhanie

thymus hyperplasia

kreatinín