aesculus assamica/protizápalový

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Steroidal constituents and anti-inflammatory activity of the horse chestnut (Aesculus hippocastanum L.) bark.

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The content and the composition of sterols in the bark of the horse chestnut, Aesculus hippocastanum L., have been examined. Stigmasterol and alpha-spinasterol were, with the beta-sitosterol, the most abundant sterols. The petrol extract from bark shows anti-inflammatory activity.

Antiinflammatory effect of Japanese horse chestnut (Aesculus turbinata) seeds.

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The antiinflammatory effects of Japanese horse chestnut (Aesculus turbinata) seeds were examined in vivo and in vitro. The extract of this seed (HCSE) inhibited croton oil-induced swelling of the mouse concha. HCSE inhibited cyclooxygenase (COX) -1 and -2 activities, but had no effect on

Antiinflammatory triterpenoid saponins from the seeds of Aesculus chinensis.

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Phytochemical study of the ethanol extract of the seeds of Aesculus chinensis led to the isolation of a new triterpenoid saponin (6), together with five known triterpenoid saponins (1-5). The structure of the new compound was elucidated on the basis of spectral data to be

Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro.

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Escin, a natural mixture of triterpenoid saponins isolated from the seed of the horse chestnut (Aesculus hippocastanum), had been demonstrated to possess anti-edematous and anti-inflammatory effects. The present study was designed to investigate whether escin exhibits synergistic anti-inflammatory

Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract.

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Horse chestnut extract (HCE), containing 70% escin, is the main active component of Veinotonyl 75. The aim of this work was to investigate pharmacological properties attempting to elucidate the efficacy of HCE in chronic venous insufficiency. Veinotonic and lymphagogue properties: HCE dose

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties.

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This review discusses historical and recent pharmacological and clinical data on the anti-edematous, anti-inflammatory, and venotonic properties of escin (Reparil^®). Escin, the active component of Aesculus hippocastanum, or horse chestnut, is available as orally absorbable dragées

Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway.

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Esculin, a coumarinic derivative found in Aesculus hippocastanum L. (Horse-chestnut), has been reported to have potent anti-inflammatory properties. The present study is designed to investigate the protective effects of esculin on various inflammation models in vivo and in vitro and to clarify the

[Anti-inflammatory effects of the extract of Aesculus hippocastanum L. (horse chesnut) seed].

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[Anti-inflammatory effect of Aesculus extract].

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Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice.

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Liver injury is an important cause of serious liver disease and is characterized by inflammatory and oxidative responses. Esculin, a coumarinic derivative found in Aesculus hippocastanum L., has been shown to exhibit anti-inflammatory and anti-oxidative effects. Here, we investigated the effects and

Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications.

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β-escin is a mixture of triterpene saponins isolated from the horse chestnut seeds (Aesculus hippocastanum L.). The anti-edematous, anti-inflammatory and venotonic properties of β-escin have been the most extensively clinically investigated effects of this plant-based drug and randomized controlled

Herbal medication: potential for adverse interactions with analgesic drugs.

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The use of herbal supplements in the US has increased dramatically in recent years. These products are not regulated by the Food and Drug Administration (FDA) with the same scrutiny as conventional drugs. Patients who use herbal supplements often do so in conjunction with conventional drugs. This

Antioxidant potential of Aesculus hippocastanum extract and escin against reactive oxygen and nitrogen species.

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OBJECTIVE Antioxidant, anti-inflammatory and venoconstrictor properties have been attributed to extracts from Aesculus hippocastanum. These unusual and diverse properties may be possibly basically linked with ability to scavenge free radicals. METHODS The scavenging capacity of dry horse chestnut

Characterisation of the antioxidant effects of Aesculus hippocastanum L. bark extract on the basis of radical scavenging activity, the chemiluminescence of human neutrophil bursts and lipoperoxidation assay.

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OBJECTIVE Oxidative stress is increasingly recognised as a pivotal factor that plays a number of roles in the inflammatory response to environmental signals. It has been claimed that Aesculus hippocastanum extracts have antioxidant and anti-inflammatory activity, but these claims are mainly based on

Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing.

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The effects of aqueous-ethanol extract of Horse chestnut (HCE) on MMP-1 and MMP-9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP-1 and MMP-9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA)

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